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[结构核酸纳米技术:液晶方法]

[Structural nucleic acid nanotechnology: liquid-crystalline approach].

作者信息

Evdokimov Iu M, Salianov V I, Kats E I, Skuridin S G

出版信息

Biofizika. 2013 Nov-Dec;58(6):987-1004.

PMID:25486757
Abstract

The properties of the particles of cholesteric liquid-crystalline dispersions formed by double-stranded DNA molecules obtained as a result of phase exclusion of these molecules from water-salt polymer-containing solutions are briefly described. Physicochemical properties of quasinematic layers of dispersion particles and double-stranded DNA molecules in their content are taken into account in the course of developing fundamental background of the liquid-crystalline approach to the DNA structural nanotechnology. According to different versions of this approach, which is based on intraparticle gelation of cholesteric liquid-crystalline dispersions, spatial structures (DNA nanoconstructions, "rigid" DNA particles) with unique properties, are created. By means of atomic force microscopy images of "rigid" DNA particles of different type are registered. Specific properties of metallic nanoparticles (in particular, gold nanoparticles) are considered while developing the other approach to DNA structural nanotechnology, which provides the basis for "metallized" DNA nanoconstructions.

摘要

简要描述了通过双链DNA分子从含盐水聚合物溶液中相排斥而获得的胆甾型液晶分散体颗粒的性质。在发展DNA结构纳米技术的液晶方法的基本背景过程中,考虑了分散体颗粒的准向列层和双链DNA分子在其含量中的物理化学性质。根据这种基于胆甾型液晶分散体内颗粒凝胶化的方法的不同版本,创建了具有独特性质的空间结构(DNA纳米结构、“刚性”DNA颗粒)。通过原子力显微镜记录了不同类型“刚性”DNA颗粒的图像。在发展DNA结构纳米技术的另一种方法时考虑了金属纳米颗粒(特别是金纳米颗粒)的特殊性质,这为“金属化”DNA纳米结构提供了基础。

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