Kavaliers M
Division of Oral Biology, Faculty of Dentistry, University of Western Ontario, London, Canada.
Brain Res Bull. 1989 May;22(5):783-5. doi: 10.1016/0361-9230(89)90020-8.
Determinations were made of the effects of beta-funaltrexamine (beta-FNA), an irreversible mu-opioid receptor antagonist, on the day-night rhythm of nociception in male mice. Peripheral administration of beta-FNA (20 and 40 mg/kg) disrupted the day-night rhythm of foot-licking response to aversive thermal (50 degrees C) stimulation. The peak nocturnal response latency was attenuated and the marked increases and decreases in response latency present at the light-dark and dark-light transitions, respectively, were suppressed. These results suggest that mu opioids are associated with the generation and expression of the day-night rhythm of this particular measure of nociception in mice.
研究了不可逆的μ-阿片受体拮抗剂β-氟纳曲胺（β-FNA）对雄性小鼠伤害感受昼夜节律的影响。外周给予β-FNA（20和40mg/kg）破坏了对厌恶热刺激（50℃）舔足反应的昼夜节律。夜间反应潜伏期峰值减弱，分别在明-暗和暗-明转换时出现的反应潜伏期显著增加和减少受到抑制。这些结果表明，μ阿片类物质与小鼠这种特定伤害感受测量的昼夜节律的产生和表达有关。
