Litvinova L S, Sokhonevich N A, Gutsol A A, Kofanova K A
Tsitologiia. 2013;55(8):566-71.
Under the experimental conditions in vitro the effects of immunoregulatory cytokines (IL-2, IL-7 and IL-15) on the activation, proliferation and apoptosis of different subpopulations of immune memory T-cell (Cd45RO+) were investigated in healthy donors. It was demonstrated that the effects of rlL-2 in vitro equally affect the activation and proliferation of CD4+ and CD8+ subpopulations of memory T cells. It has been shown that high concentrations of rIL-2 lead to an increase in the number of CD8+ memory cells expressing apoptotic molecule CD95. Different effect of rIL-7 and rIL-15 on the activation and proliferation of cytotoxic CD8+ memory ells has been revealed in vitro. CD4+ memory lymphocytes have relative resistance to the activation and proliferative effect of rlL-7 and rlL-15, if compared with the effects of rIL-2, which can provide their relative resistance to the activation apoptosis as well as create the necessary conditions for the accelerated implementation of their functional capacity in the development of a secondary immune response.
在体外实验条件下，研究了免疫调节细胞因子（IL-2、IL-7和IL-15）对健康供体中免疫记忆T细胞（Cd45RO+）不同亚群的激活、增殖和凋亡的影响。结果表明，rlL-2在体外对记忆T细胞的CD4+和CD8+亚群的激活和增殖具有同等作用。研究表明，高浓度的rlL-2会导致表达凋亡分子CD95的CD8+记忆细胞数量增加。体外实验揭示了rIL-7和rIL-15对细胞毒性CD8+记忆细胞激活和增殖的不同作用。与rlL-2的作用相比，CD4+记忆淋巴细胞对rlL-7和rlL-15的激活和增殖作用具有相对抗性，这可以为它们提供对激活凋亡的相对抗性，并为在二次免疫反应发展中加速发挥其功能能力创造必要条件。
