Kim Bumki, Hong Jiyong
Duke University, Department of Chemistry, 124 Science Drive, Box 90346, Durham, NC 27708, USA.
Curr Top Med Chem. 2015;14(24):2759-82. doi: 10.2174/1568026615666141208105614.
Histone deacetylases (HDACs) have recently emerged as key elements in epigenetic control of gene expression. Due to the implication of HDACs in a variety of diseases ranging from cancer to neurodegenerative disorder, HDAC inhibitors have received increased attention in recent years. Over the last few decades, a myriad of HDAC inhibitors containing a wide variety of structural features have been identified from natural sources. Here, we review the discovery, synthesis, biological properties, and modes of action of these naturally occurring HDAC inhibitors and consider their implications for future research.
组蛋白脱乙酰酶（HDACs）最近已成为基因表达表观遗传控制中的关键要素。由于HDACs涉及从癌症到神经退行性疾病等多种疾病，近年来HDAC抑制剂受到了越来越多的关注。在过去几十年中，已从天然来源鉴定出无数具有各种结构特征的HDAC抑制剂。在此，我们综述这些天然存在的HDAC抑制剂的发现、合成、生物学特性和作用模式，并考虑它们对未来研究的意义。
