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原发性胃旁路手术及因可调节胃束带术失败而进行的翻修胃旁路手术的五年体重减轻情况:一项病例匹配研究的结果

Five-year weight loss in primary gastric bypass and revisional gastric bypass for failed adjustable gastric banding: results of a case-matched study.

作者信息

Thereaux Jérémie, Corigliano Nicola, Poitou Christine, Oppert Jean-Michel, Czernichow Sebastien, Bouillot Jean-Luc

机构信息

Department of General, Digestive and Metabolic Surgery, Ambroise Paré University Hospital, Versailles Saint-Quentin University, Assistance Publique- Hôpitaux de Paris, 9, Avenue Charles de Gaulle, 92100 Boulogne, France.

Department of Nutrition, Pitié-Salpêtrière Hospital, Assistance Publique- Hôpitaux de Paris, Pierre-et-Marie-Curie-Paris 6 University, Human Nutrition Research Center Île-de-France (CRNH IdF), Institute of cardiometabolic disease and nutrition (ICAN), 83, boulevard de l'Hôpital, 75013 Paris, France.

出版信息

Surg Obes Relat Dis. 2015 Jan-Feb;11(1):19-25. doi: 10.1016/j.soard.2014.05.033. Epub 2014 Jun 5.

Abstract

BACKGROUND

Despite their now frequent use, the long-term results for adjustable gastric bands are variable and often less than gastric bypass. Laparoscopic Roux-en-Y gastric bypass (LRYGB) provides good early results and seems to be the revisional procedure of choice. Nevertheless, the long-term outcomes following revisional LRYGB (rLRYGB) for failed adjustable gastric banding have not been compared with those for primary LRYGB (pLRYGB).

METHODS

The objective was to compare weight loss and changes in obesity related co-morbidities 5 years after pLRYGB and rLRYGB for failed adjustable gastric banding. The prospective database of a single surgery university center (Paris, France) was queried for clinical and other relevant data. From January 2004 to September 2008, 58 and 272 patients have undergone rLRYGB and pLRYGB, respectively. Rate of lost to follow-up was 13.3%. We matched 45 patients undergoing rLRYGB (case group) with 45 undergoing pLRYGB (control group) for age, sex, and initial body mass index (BMI).

RESULTS

Case and control groups did not differ for initial BMI (46.9±7.2 versus 46.9±7.5 kg/m²; P=.99), age (43.4±9.4 versus 43.6±9.8y; P=.91), or sex ratio (91.1% female, P=.99). The rates of coexisting conditions in the 2 groups were similar. At 5 years, weight loss (kg) (39.9±16.4 versus 31.4±15.8; P=.02), percentage of weight loss (%) (30.8±9.8 versus 24.8±11.5; P=.03), and percentage of excess weight loss (%) (68.4±20.6 versus 55.7±26.3; P=.007) were higher for pLRYGB than rLRYGB. Rates of remission and improvement of coexisting conditions were similar.

CONCLUSION

After 5 years of follow-up, pLRYGB provides greater weight loss than rLRYGB with similar rates of improvement and remission of coexisting conditions. Patients and surgeons should be aware of such results before primary and revisional bariatric surgery.

摘要

背景

尽管可调节胃束带目前使用频繁,但其长期效果不一,且往往不如胃旁路手术。腹腔镜Roux-en-Y胃旁路术(LRYGB)早期效果良好,似乎是首选的修正手术方式。然而,针对失败的可调节胃束带进行修正LRYGB(rLRYGB)后的长期结果尚未与初次LRYGB(pLRYGB)的结果进行比较。

方法

目的是比较pLRYGB和rLRYGB治疗失败的可调节胃束带5年后的体重减轻情况以及肥胖相关合并症的变化。查询了一所单一外科大学中心(法国巴黎)的前瞻性数据库以获取临床和其他相关数据。2004年1月至2008年9月,分别有58例和272例患者接受了rLRYGB和pLRYGB。失访率为13.3%。我们将45例接受rLRYGB的患者(病例组)与45例接受pLRYGB的患者(对照组)按年龄、性别和初始体重指数(BMI)进行匹配。

结果

病例组和对照组在初始BMI(46.9±7.2对46.9±7.5kg/m²;P = 0.99)、年龄(43.4±9.4对43.6±9.8岁;P = 0.91)或性别比例(女性占91.1%,P = 0.99)方面无差异。两组并存疾病的发生率相似。5年后,pLRYGB的体重减轻(kg)(39.9±16.4对31.4±15.8;P = 0.02)、体重减轻百分比(%)(30.8±9.8对24.8±11.5;P = 0.03)以及超重减轻百分比(%)(68.4±20.6对55.7±26.3;P = 0.007)均高于rLRYGB。并存疾病的缓解率和改善率相似。

结论

经过5年的随访,pLRYGB比rLRYGB减重更多,并存疾病的改善率和缓解率相似。患者和外科医生在初次和修正减重手术前应了解这些结果。

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