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原发性痛经患者中 incidental brain findings 的高患病率。 需注意,这里“incidental brain findings”可能是“偶然发现的脑部病变”之类的意思,但由于原文未详细解释,准确含义可能需结合更多背景信息判断 。 你可根据实际情况调整表述。 仅按字面翻译是上述译文 。

High prevalence of incidental brain findings in primary dysmenorrhoea.

作者信息

Li W C, Tu C H, Chao H T, Yeh T C, Chen L F, Hsieh J C

机构信息

Institute of Brain Science, School of Medicine, National Yang-Ming University, Taipei, Taiwan.

Integrated Brain Research Unit, Division of Clinical Research, Department of Medical Research, Taipei Veterans General Hospital, Taiwan.

出版信息

Eur J Pain. 2015 Sep;19(8):1071-4. doi: 10.1002/ejp.639. Epub 2014 Dec 8.

Abstract

BACKGROUND

Primary dysmenorrhoea (PDM) is inexorably common. PDM women suffer from cramping pain in the lower abdomen that starts with menstruation and lasts for 24-72 h. Up to 90% of adolescent girls and more than 50% of menstruating women worldwide report suffering from it. Ten to 20% of PDM women describe their suffering as severe and distressing. However, nothing is known regarding the association of PDM with possible brain anomalies or abnormalities.

METHODS

High-resolution T1-weighted anatomical brain magnetic resonance images (MRI) were acquired for each subject and inspected for incidental findings (normal variants and abnormalities) as a routine procedure in our PDM-related multimodal neuroimaging studies. Altogether, 330 right-handed young women [otherwise healthy PDMs = 163; non-PDM healthy controls (HCs) = 167] were enrolled during the period of 2006-2014. Binomial proportion test was performed for between-group comparisons.

RESULTS

PDMs demonstrated significantly higher prevalence of overall incidental brain MRI findings (PDMs: n = 18, 11.0%; HCs: n = 6, 3.6%; p = 0.005) that should be ascribed to a preponderance of normal variants (PDMs: n = 16, 9.8%; HCs: n = 3, 1.8%; p = 0.001), especially cavum septum pellucidum. No significant between-group difference of abnormal findings was found (PDMs: n = 2, 1.2%; HCs: n = 3, 1.8%; p = 0.336).

CONCLUSIONS

We report here that otherwise healthy PDMs are associated with high prevalence of normal variants but not brain abnormalities. Our observations invite further epidemiological and neuroscientific studies.

摘要

背景

原发性痛经(PDM)极为常见。患有PDM的女性会经历下腹部痉挛性疼痛,该疼痛始于月经来潮并持续24 - 72小时。全球多达90%的青春期女孩和超过50%的成年女性报告患有此病。10%至20%的PDM女性称其痛苦程度严重且令人苦恼。然而,关于PDM与可能的脑部异常或畸形之间的关联尚无定论。

方法

在我们与PDM相关的多模态神经影像学研究中,为每位受试者采集了高分辨率T1加权脑部解剖磁共振成像(MRI),并将偶然发现(正常变异和异常)作为常规检查项目。2006年至2014年期间,共纳入了330名右利手年轻女性[健康的PDM患者 = 163名;非PDM健康对照(HCs)= 167名]。采用二项比例检验进行组间比较。

结果

PDM患者总体脑部MRI偶然发现的患病率显著更高(PDM患者:n = 18,11.0%;HCs:n = 6,3.6%;p = 0.005),这主要归因于正常变异占优势(PDM患者:n = 16,9.8%;HCs:n = 3,1.8%;p = 0.001),尤其是透明隔腔。未发现异常发现的组间显著差异(PDM患者:n = 2,1.2%;HCs:n = 3,1.8%;p = 0.336)。

结论

我们在此报告,健康的PDM患者与正常变异的高患病率相关,但与脑部异常无关。我们的观察结果有待进一步的流行病学和神经科学研究。

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