基于磁共振成像的股骨近端微结构有限元分析在体内评估骨强度的测量可重复性。
Measurement reproducibility of magnetic resonance imaging-based finite element analysis of proximal femur microarchitecture for in vivo assessment of bone strength.
作者信息
Chang Gregory, Hotca-Cho Alexandra, Rusinek Henry, Honig Stephen, Mikheev Artem, Egol Kenneth, Regatte Ravinder R, Rajapakse Chamith S
机构信息
Department of Radiology, Center for Biomedical Imaging, NYU Langone Medical Center, 660 First Avenue, Room 334, 3rd Floor, New York, NY, 10016, USA,
出版信息
MAGMA. 2015 Aug;28(4):407-12. doi: 10.1007/s10334-014-0475-y. Epub 2014 Dec 9.
INTRODUCTION
Osteoporosis is a disease of weak bone. Our goal was to determine the measurement reproducibility of magnetic resonance assessment of proximal femur strength.
METHODS
This study had institutional review board approval, and written informed consent was obtained from all subjects. We obtained images of proximal femur microarchitecture by scanning 12 subjects three times within 1 week at 3T using a high-resolution 3-D FLASH sequence. We applied finite element analysis to compute proximal femur stiffness and femoral neck elastic modulus.
RESULTS
Within-day and between-day root-mean-square coefficients of variation and intraclass correlation coefficients ranged from 3.5 to 6.6 % and 0.96 to 0.98, respectively.
CONCLUSION
The measurement reproducibility of magnetic resonance assessment of proximal femur strength is suitable for clinical studies of disease progression or treatment response related to osteoporosis bone-strengthening interventions.
引言
骨质疏松症是一种骨骼脆弱的疾病。我们的目标是确定磁共振评估股骨近端强度的测量可重复性。
方法
本研究获得了机构审查委员会的批准，并获得了所有受试者的书面知情同意书。我们使用高分辨率三维快速成像稳态进动序列，在3T条件下于1周内对12名受试者的股骨近端微结构进行了三次扫描，获取图像。我们应用有限元分析来计算股骨近端刚度和股骨颈弹性模量。
结果
日内和日间的均方根变异系数以及组内相关系数分别在3.5%至6.6%和0.96至0.98之间。
结论
磁共振评估股骨近端强度的测量可重复性适用于与骨质疏松症骨骼强化干预相关的疾病进展或治疗反应的临床研究。
Zotero 插件