Division of Arthritis & Rheumatic Diseases (OP09), Oregon Health & Science University, Portland, OR, USA.
Department of Rheumatology, University of Ghent, Ghent, Belgium.
Best Pract Res Clin Rheumatol. 2014 Oct;28(5):663-72. doi: 10.1016/j.berh.2014.10.007. Epub 2014 Nov 18.
The term spondyloarthritis (SpA) encompasses a group of diseases characterized by inflammation in the spine and in the peripheral joints, and other clinical features such as uveitis, dactylitis, psoriasis, inflammatory bowel disease, and association with human leukocyte antigen (HLA) B27. The spectrum of SpA encompasses axial spondyloarthritis (axSpA) and peripheral spondyloarthritis including psoriatic arthritis (PsA), reactive arthritis (ReA), and inflammatory bowel disease-associated arthritis. In recent years, there has been tremendous progress in understanding the natural history and pathogenetic mechanisms underlying SpA leading to the development of effective treatments. It has become imperative to identify the disease early, and accurately, to avail patients of effective treatments in a safe manner. The development of the Assessment of SpondyloArthritis International Society (ASAS) classification criteria has been a welcome advance in this regard. This article provides a historical evolution of the concept of SpA, from the Rome Criteria to the ASAS criteria, current issues and barriers with the use of ASAS criteria, and the work that still needs to be done moving forward.
术语脊柱关节炎（SpA）包括一组以脊柱和外周关节炎症为特征的疾病，以及其他临床特征，如葡萄膜炎、指（趾）炎、银屑病、炎症性肠病和与人类白细胞抗原（HLA）B27 相关。SpA 的范围包括中轴型脊柱关节炎（axSpA）和外周型脊柱关节炎，包括银屑病关节炎（PsA）、反应性关节炎（ReA）和炎症性肠病相关关节炎。近年来，人们对 SpA 的自然史和发病机制有了深入的了解，从而开发出有效的治疗方法。早期、准确地识别疾病，并以安全的方式为患者提供有效治疗已变得至关重要。评估脊柱关节炎国际学会（ASAS）分类标准的制定是这方面的一个可喜进展。本文提供了 SpA 概念的历史演变，从罗马标准到 ASAS 标准，当前使用 ASAS 标准的问题和障碍，以及未来仍需要做的工作。
