Gurtu S, Pant K K, Sinha J N
Indian J Med Res. 1989 Jun;90:209-14.
Intravenous veratrine induced alterations in cardiovascular parameters in cats were used as a tool for assessing the influence of central alpha-adrenoceptors over reflex adjustments in the heart rate and blood pressure. Blockade of central alpha 2-adrenoceptors with idazoxan or yohimbine, inhibited, while their activation by clonidine, as also blockade of alpha 1-adrenoceptors, with prazosin, potentiated the veratrine induced bradycardia. The hypotensive effect was relatively unaltered by these treatments. Low doses of clonidine potentiated the veratrine-induced bradycardia. It appears that alpha 2-adrenoceptor mechanisms exert greater control over the reflex regulation of heart rate than over reflex control of blood pressure.
静脉注射藜芦碱引起猫心血管参数的改变，以此作为评估中枢α-肾上腺素能受体对心率和血压反射调节影响的工具。用咪唑克生或育亨宾阻断中枢α2-肾上腺素能受体会抑制这种影响，而可乐定激活它们以及用哌唑嗪阻断α1-肾上腺素能受体则会增强藜芦碱诱导的心动过缓。这些处理对降压作用影响相对较小。低剂量可乐定增强了藜芦碱诱导的心动过缓。似乎α2-肾上腺素能受体机制对心率反射调节的控制作用比对血压反射控制的作用更大。
