Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA; Department of Medical Oncology, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02215, USA.
Cancer Cell. 2014 Dec 8;26(6):779-780. doi: 10.1016/j.ccell.2014.11.022.
Reprogramming of cellular metabolism by oncogenic mutations probably creates specific vulnerabilities that could be exploited therapeutically. In this issue of Cancer Cell, Sourbier and colleagues show that kidney cancers lacking fumarate hydratase display increased sensitivity to agents that interfere with their ability to cope with reactive oxygen species.
致癌突变对细胞代谢的重新编程可能会产生特定的弱点，这些弱点可以被治疗方法利用。在本期《癌细胞》杂志中，Sourbier 及其同事表明，缺乏延胡索酸水合酶的肾癌对干扰其应对活性氧能力的药物更为敏感。
