含WW结构域的肿瘤抑制氧化还原酶调节细胞代谢。
The tumor suppressor WW domain-containing oxidoreductase modulates cell metabolism.
作者信息
Abu-Remaileh Muhannad, Aqeilan Rami I
机构信息
The Lautenberg Center for General and Tumor Immunology, Department of Immunology and Cancer Research-IMRIC, Hebrew University-Hadassah Medical School, Jerusalem 91220, Israel.
The Lautenberg Center for General and Tumor Immunology, Department of Immunology and Cancer Research-IMRIC, Hebrew University-Hadassah Medical School, Jerusalem 91220, Israel Department of Molecular Virology, Immunology and Medical Genetics, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USA
出版信息
Exp Biol Med (Maywood). 2015 Mar;240(3):345-50. doi: 10.1177/1535370214561956. Epub 2014 Dec 8.
The WW domain-containing oxidoreductase (WWOX) encodes a tumor suppressor that is frequently altered in cancer. WWOX binds several proteins and thus is postulated to be involved in a variety of cellular processes. Interestingly, Wwox-knockout mice develop normally in utero but succumb to hypoglycemia and other metabolic defects early in life resulting in their death by 3-4 weeks of age. Cumulative evidence has linked WWOX with cellular metabolism including steroid metabolism, high-density lipoprotein cholesterol (HDL-C) metabolism, bone metabolism and, more recently, glucose metabolism. In this review, we discuss these evolving functions for WWOX and how its deletion affects cellular metabolism and neoplastic progression.
含WW结构域的氧化还原酶（WWOX）编码一种肿瘤抑制因子，在癌症中经常发生改变。WWOX与多种蛋白质结合，因此推测它参与多种细胞过程。有趣的是，Wwox基因敲除小鼠在子宫内发育正常，但在生命早期就会死于低血糖和其他代谢缺陷，导致它们在3至4周龄时死亡。越来越多的证据表明WWOX与细胞代谢有关，包括类固醇代谢、高密度脂蛋白胆固醇（HDL-C）代谢、骨代谢，以及最近发现的葡萄糖代谢。在这篇综述中，我们讨论了WWOX这些不断演变的功能，以及它的缺失如何影响细胞代谢和肿瘤进展。
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