The Concern Foundation Laboratories, The Lautenberg Center for Immunology and Cancer Research, Department of Immunology and Cancer Research-IMRIC, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem 91120, Israel.
Cells. 2021 Nov 9;10(11):3082. doi: 10.3390/cells10113082.
The WW domain-containing oxidoreductase () gene was originally discovered as a putative tumor suppressor spanning the common fragile site FRA16D, but as time has progressed the extent of its pleiotropic function has become apparent. At present, WWOX is a major source of interest in the context of neurological disorders, and more specifically developmental and epileptic encephalopathies (DEEs). This review article aims to introduce the many model systems used through the years to study its function and roles in neuropathies. Similarities and fundamental differences between rodent and human models are discussed. Finally, future perspectives and promising research avenues are suggested.
WW 结构域包含氧化还原酶（）基因最初被发现是跨越常见脆性位点 FRA16D 的假定肿瘤抑制因子，但随着时间的推移，其多功能性的程度变得明显。目前，WWOX 是神经紊乱，特别是发育性和癫痫性脑病（DEE）领域的主要研究热点。本文综述旨在介绍多年来用于研究其在神经病变中的功能和作用的多种模型系统。讨论了啮齿动物和人类模型之间的相似性和根本差异。最后，提出了未来的展望和有前途的研究方向。
