光学冠状动脉断层扫描在定量测量富含脂质斑块的冠状动脉中的可行性。
Feasibility of optical coronary tomography in quantitative measurement of coronary arteries with lipid-rich plaque.
作者信息
Kubo Takashi, Yamano Takashi, Liu Yong, Ino Yasushi, Shiono Yasutsugu, Orii Makoto, Taruya Akira, Nishiguchi Tsuyoshi, Shimokado Aiko, Teraguchi Ikuko, Tanimoto Takashi, Kitabata Hironori, Yamaguchi Tomoyuki, Hirata Kumiko, Tanaka Atsuhi, Akasaka Takashi
机构信息
Department of Cardiovascular Medicine, Wakayama Medical University.
出版信息
Circ J. 2015;79(3):600-6. doi: 10.1253/circj.CJ-14-1085. Epub 2014 Dec 10.
BACKGROUND
The aim of the present study was to evaluate the feasibility of optical coherence tomography (OCT) for measurement of vessel area in coronary arteries with lipid-rich plaque as compared with intravascular ultrasound (IVUS). METHODS AND RESULTS: We investigated 80 coronary artery segments with lipid-rich plaque on OCT and non-attenuated plaque on IVUS. According to the lipid arc on OCT, the plaques were classified into 4 groups: group 1, lipid arc ≤90°; group 2, 90°<lipid arc≤180°; group 3, 180°<lipid arc≤270°; group 4, lipid arc >270°. Vessel circular arcs that could not be identified due to OCT signal attenuation were interpolated using an approximating algorithm. OCT-measured vessel area was well-correlated with IVUS-measured vessel area (R=0.834, P<0.001). On Bland-Altman plot, there was a good agreement between OCT-measured vessel area and IVUS-measured vessel area, although mean difference and limits of agreement increased with increase of lipid arc (mean difference in groups 1-4: -0.21, -0.31, -1.02, and -2.13 mm(2); lower limit: -1.49, -3.22, -5.24, and -9.25 mm(2); and upper limit: 1.07, 2.60, 3.20, and 4.99 mm(2)). Intra-observer (R=0.97-0.99, P<0.001) and inter-observer (R=0.97-0.99, P<0.001) reproducibility for OCT measurement of vessel area was excellent.
CONCLUSIONS
Like IVUS, OCT can be used to measure vessel area in coronary arteries with lipid-rich plaque.
背景
本研究的目的是评估光学相干断层扫描（OCT）测量富含脂质斑块的冠状动脉血管面积的可行性，并与血管内超声（IVUS）进行比较。方法与结果：我们对80个冠状动脉节段进行了研究，这些节段在OCT上显示为富含脂质斑块，在IVUS上显示为无衰减斑块。根据OCT上的脂质弧，将斑块分为4组：第1组，脂质弧≤90°；第2组，90°＜脂质弧≤180°；第3组，180°＜脂质弧≤270°；第4组，脂质弧＞270°。因OCT信号衰减而无法识别的血管圆弧采用近似算法进行插值。OCT测量的血管面积与IVUS测量的血管面积具有良好的相关性（R = 0.834，P＜0.001）。在Bland-Altman图上，OCT测量的血管面积与IVUS测量的血管面积之间具有良好的一致性，尽管平均差异和一致性界限随脂质弧的增加而增加（第1 - 4组的平均差异：-0.21、-0.31、-1.02和-2.13 mm²；下限：-1.49、-3.22、-5.24和-9.25 mm²；上限：1.07、2.60、3.20和4.99 mm²）。OCT测量血管面积的观察者内（R = 0.97 - 0.99，P＜0.001）和观察者间（R = 0.97 - 0.99，P＜0.001）重复性极佳。结论：与IVUS一样，OCT可用于测量富含脂质斑块的冠状动脉血管面积。
Zotero 插件