Wazir Umar, Manson Aisling, Mokbel Kefah
Umar Wazir, Aisling Manson, Kefah Mokbel, The London Breast Institute, Princess Grace Hospital, London W1U 5NY, United Kingdom.
World J Clin Oncol. 2014 Dec 10;5(5):792-4. doi: 10.5306/wjco.v5.i5.792.
The sentinel lymph node biopsy (SLNB) was initially pioneered for staging melanoma in 1994 and it has been subsequently validated by several trials, and has become the new standard of care for patients with clinically node negative invasive breast cancer. The focussed examination of fewer lymph nodes in addition to improvements in histopathological and molecular analysis has increased the rate at which micrometastases and isolated tumour cells are identified. In this article we review the literature regarding the optimal management of the axilla when the SLNB is positive for metastatic disease based on level 1 evidence derived from randomised clinical trials.
前哨淋巴结活检(SLNB)最初于1994年被用于黑色素瘤分期,随后经过多项试验验证,已成为临床腋窝淋巴结阴性浸润性乳腺癌患者的新治疗标准。除了在组织病理学和分子分析方面有所改进外,对较少淋巴结的重点检查提高了微转移和孤立肿瘤细胞的检出率。在本文中,我们基于随机临床试验得出的一级证据,回顾了有关前哨淋巴结活检转移性疾病呈阳性时腋窝最佳管理的文献。