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利用蒙特卡罗方法开发 Vero4DRT 的剂量验证系统。

Development of a dose verification system for Vero4DRT using Monte Carlo method.

机构信息

Department of Radiation Oncology and Image-applied Therapy, Kyoto University.

出版信息

J Appl Clin Med Phys. 2014 Nov 8;15(6):4961. doi: 10.1120/jacmp.v15i6.4961.

Abstract

Vero4DRT is an innovative image-guided radiotherapy system employing a C-band X-ray head with gimbal mechanics. The purposes of this study were to propose specific MC models of the linac head and multileaf collimator (MLC) for the Vero4DRT and to verify their accuracy. For a 6 MV photon beam delivered by the Vero4DRT, a simulation code was implemented using EGSnrc. The linac head model and the MLC model were simulated based on its specification. Next, the percent depth dose (PDD) and beam profiles at depths of 15, 100, and 200 mm were simulated under source-to-surface distance of 900 and 1000 mm. Field size was set to 150 × 150 mm2 at a depth of 100 mm. Each of the simulated dosimetric metrics was then compared with the corresponding measurements by a 0.125 cc ionization chamber. After that, intra- and interleaf leakage, tongue-and-groove, and rounded-leaf profiles were simulated for the static MLC model. Meanwhile, film measurements were performed using EDR2 films under similar conditions to simulation. The measurement for the rounded-leaf profile was performed using the water phantom and the ionization chamber. The leaf physical density and abutting leaf gap were adjusted to obtain good agreement between the simulated intra- and interleaf leakage profiles and measurements. For the MLC model in step-and-shoot cases, a pyramid and a prostate IMRT field were simulated, while film measurements were performed using EDR2. For the linac head, exclusive of MLC, the difference in PDD was < 1.0% after the buildup region. The simulated beam profiles agreed to within 1.3% at each depth. The MLC model has been shown to reproduce dose measurements within 2.5% for static tests. The MLC is made of tungsten alloy with a purity of 95%. The leaf gap of 0.015 cm and the MLC physical density of 18.0 g/ cm3, which provided the best agreement between the simulated and measured leaf leakage, were assigned to our MC model. As a result, the simulated step-and-shoot IMRT dose distributions agreed with the film measurements to within 3.3%, with exception of the penumbra region. We have developed specific MC models of the linac head and the MLC in the Vero4DRT system. The results have demonstrated that our MC models have high accuracy.

摘要

Vero4DRT 是一种采用带万向架机械结构的 C 波段 X 射线头的创新图像引导放射治疗系统。本研究的目的是为 Vero4DRT 提出特定的直线加速器头和多叶准直器 (MLC) 的 MC 模型,并验证其准确性。对于由 Vero4DRT 提供的 6 MV 光子束,使用 EGSnrc 实现了模拟代码。根据其规格模拟了直线加速器头模型和 MLC 模型。接下来,在源皮距为 900 和 1000 mm 时,模拟了深度为 15、100 和 200 mm 处的百分深度剂量 (PDD) 和射束轮廓。在 100 mm 深度处将射野大小设置为 150×150 mm2。然后,将每个模拟剂量学指标与 0.125 cc 电离室的相应测量值进行比较。之后,为静态 MLC 模型模拟了内叶和外叶泄漏、楔形和圆形叶轮廓。同时,在类似的条件下使用 EDR2 胶片进行了膜测量。使用水模和电离室进行了圆形叶轮廓的测量。调整叶片物理密度和相邻叶片间隙,以获得模拟内叶和外叶泄漏轮廓与测量值之间的良好一致性。对于步进式 MLC 模型,模拟了一个金字塔和一个前列腺调强放疗野,同时使用 EDR2 进行了膜测量。对于不包括 MLC 的直线加速器头,在建成区之后 PDD 的差异 < 1.0%。在每个深度处,模拟射束轮廓的差异都在 1.3%以内。结果表明,MLC 模型在静态测试中可以将剂量测量值的重复性控制在 2.5%以内。MLC 由纯度为 95%的钨合金制成。我们的 MC 模型将叶片间隙 0.015 cm 和 MLC 物理密度 18.0 g/cm3 分配给 MLC,因为它们提供了模拟和测量叶片泄漏之间的最佳一致性。结果,模拟的步进式调强放疗剂量分布与膜测量值的一致性在 3.3%以内,除了半影区域。我们已经为 Vero4DRT 系统中的直线加速器头和 MLC 开发了特定的 MC 模型。结果表明,我们的 MC 模型具有很高的准确性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/21c0/5711115/2b79858ffa0d/ACM2-15-160-g001.jpg

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