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与强直性脊柱炎或弥漫性特发性骨肥厚相关的颈椎和颈胸段骨折后路长节段内固定术后的并发症及生存率

Complications and survival after long posterior instrumentation of cervical and cervicothoracic fractures related to ankylosing spondylitis or diffuse idiopathic skeletal hyperostosis.

作者信息

Robinson Yohan, Robinson Anna-Lena, Olerud Claes

机构信息

From the Department of Surgical Sciences, Uppsala University Hospital, Uppsala, Sweden.

出版信息

Spine (Phila Pa 1976). 2015 Feb 15;40(4):E227-33. doi: 10.1097/BRS.0000000000000726.

Abstract

STUDY DESIGN

Prospective cohort study.

OBJECTIVE

This study investigates the results of long posterior instrumentation with regard to complications and survival.

SUMMARY OF BACKGROUND DATA

Fractures of the cervical spine and the cervicothoracic junction related to ankylosing spinal disease (ASD) endanger both sagittal profile and spinal cord. Both anterior and posterior stabilization methods are well established, and clear treatment guidelines are missing.

METHODS

Forty-one consecutive patients with fractures of the cervicothoracic junction related to ASD were treated by posterior instrumentation. All patients were followed prospectively for 2 years using a standardized protocol.

RESULTS

Five patients experienced postoperative infections, 3 patients experienced postoperative pneumonia, 2 patients required postoperative tracheostomy, and 1 patient had postoperative cerebrospinal fluid leakage due to accidental durotomy. No patient required reoperation due to implant failure or nonunion. Mean survival was 52 months (95% confidence interval: 42-62 mo). Survival was affected by patient age, sex, smoking, and spinal cord injury.

CONCLUSION

Patients with ASD experiencing a fracture of the cervicothoracic region are at high risk of developing complications. The posterior instrumentation of cervical spinal fractures related to ASD is recommended due to biomechanical superiority.

LEVEL OF EVIDENCE

摘要

研究设计

前瞻性队列研究。

目的

本研究调查长节段后路内固定术在并发症和生存率方面的结果。

背景资料总结

与强直性脊柱炎相关的颈椎和颈胸段交界处骨折会危及矢状面形态和脊髓。前后路稳定方法均已成熟,但缺乏明确的治疗指南。

方法

对41例与强直性脊柱炎相关的颈胸段交界处骨折患者采用后路内固定术治疗。所有患者均采用标准化方案进行前瞻性随访2年。

结果

5例患者发生术后感染,3例患者发生术后肺炎,2例患者术后需要气管切开,1例患者因意外硬膜切开术导致术后脑脊液漏。无患者因内植物失败或骨不连需要再次手术。平均生存期为52个月(95%置信区间:42 - 62个月)。生存期受患者年龄、性别、吸烟和脊髓损伤影响。

结论

强直性脊柱炎患者发生颈胸段骨折时发生并发症的风险较高。由于生物力学优势,建议对与强直性脊柱炎相关的颈椎骨折采用后路内固定术。

证据等级

4级。

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