• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Chromatin modification by the RNA Polymerase II elongation complex.RNA聚合酶II延伸复合物介导的染色质修饰。
Transcription. 2014;5(5):e988093. doi: 10.4161/21541264.2014.988093. Epub 2015 Jan 7.
2
A positive feedback loop links opposing functions of P-TEFb/Cdk9 and histone H2B ubiquitylation to regulate transcript elongation in fission yeast.正反馈环将 P-TEFb/Cdk9 和组蛋白 H2B 泛素化的相反功能联系起来，以调节裂殖酵母中转录延伸。
PLoS Genet. 2012;8(8):e1002822. doi: 10.1371/journal.pgen.1002822. Epub 2012 Aug 2.
3
Cyclin-dependent kinase control of the initiation-to-elongation switch of RNA polymerase II.细胞周期蛋白依赖性激酶对 RNA 聚合酶 II 起始延伸转换的调控。
Nat Struct Mol Biol. 2012 Nov;19(11):1108-15. doi: 10.1038/nsmb.2399. Epub 2012 Oct 14.
4
Functional interaction of Rpb1 and Spt5 C-terminal domains in co-transcriptional histone modification.转录共调控组蛋白修饰中Rpb1和Spt5 C末端结构域的功能相互作用
Nucleic Acids Res. 2015 Nov 16;43(20):9766-75. doi: 10.1093/nar/gkv837. Epub 2015 Aug 14.
5
Cdk9 is an essential kinase in Drosophila that is required for heat shock gene expression, histone methylation and elongation factor recruitment.细胞周期蛋白依赖性激酶9（Cdk9）是果蝇中的一种必需激酶，在热休克基因表达、组蛋白甲基化和延伸因子募集过程中发挥作用。
Mol Genet Genomics. 2007 Feb;277(2):101-14. doi: 10.1007/s00438-006-0164-2. Epub 2006 Sep 26.
6
TFIIH-associated Cdk7 kinase functions in phosphorylation of C-terminal domain Ser7 residues, promoter-proximal pausing, and termination by RNA polymerase II.与TFIIH相关的Cdk7激酶在RNA聚合酶II介导的C末端结构域Ser7残基磷酸化、启动子近端暂停和终止过程中发挥作用。
Mol Cell Biol. 2009 Oct;29(20):5455-64. doi: 10.1128/MCB.00637-09. Epub 2009 Aug 10.
7
Insights into the function of the human P-TEFb component CDK9 in the regulation of chromatin modifications and co-transcriptional mRNA processing.深入了解人类 P-TEFb 成分 CDK9 在调节染色质修饰和共转录 mRNA 加工中的作用。
Cell Cycle. 2009 Nov 15;8(22):3636-42. doi: 10.4161/cc.8.22.9890. Epub 2009 Nov 24.
8
Coordination of transcription factor phosphorylation and histone methylation by the P-TEFb kinase during human immunodeficiency virus type 1 transcription.人免疫缺陷病毒1型转录过程中P-TEFb激酶对转录因子磷酸化和组蛋白甲基化的协调作用。
J Virol. 2004 Dec;78(24):13522-33. doi: 10.1128/JVI.78.24.13522-13533.2004.
9
Tat modifies the activity of CDK9 to phosphorylate serine 5 of the RNA polymerase II carboxyl-terminal domain during human immunodeficiency virus type 1 transcription.在1型人类免疫缺陷病毒转录过程中，Tat修饰CDK9的活性，使其对RNA聚合酶II羧基末端结构域的丝氨酸5进行磷酸化。
Mol Cell Biol. 2000 Jul;20(14):5077-86. doi: 10.1128/MCB.20.14.5077-5086.2000.
10
Human TFIIH Kinase CDK7 Regulates Transcription-Associated Chromatin Modifications.人类转录因子IIH激酶CDK7调节转录相关的染色质修饰。
Cell Rep. 2017 Aug 1;20(5):1173-1186. doi: 10.1016/j.celrep.2017.07.021.

引用本文的文献

1
The Rtf1/Prf1-dependent histone modification axis counteracts multi-drug resistance in fission yeast.Rtf1/Prf1 依赖性组蛋白修饰轴可拮抗裂殖酵母的多药耐药性。
Life Sci Alliance. 2024 Mar 21;7(6). doi: 10.26508/lsa.202302494. Print 2024 Jun.
2
Non-canonical MLL1 activity regulates centromeric phase separation and genome stability.非规范的 MLL1 活性调节着着丝粒的相分离和基因组稳定性。
Nat Cell Biol. 2023 Nov;25(11):1637-1649. doi: 10.1038/s41556-023-01270-1. Epub 2023 Nov 9.
3
HOS15 represses flowering by promoting GIGANTEA degradation in response to low temperature in Arabidopsis.HOS15 通过促进 GI 降解来响应低温抑制拟南芥开花。
Plant Commun. 2023 Jul 10;4(4):100570. doi: 10.1016/j.xplc.2023.100570. Epub 2023 Mar 2.
4
Decoding histone ubiquitylation.解码组蛋白泛素化
Front Cell Dev Biol. 2022 Aug 29;10:968398. doi: 10.3389/fcell.2022.968398. eCollection 2022.
5
The establishment of CDK9/RNA PolII/H3K4me3/DNA methylation feedback promotes HOTAIR expression by RNA elongation enhancement in cancer.CDK9/RNA PolII/H3K4me3/DNA 甲基化反馈通过增强 RNA 延伸促进癌症中 HOTAIR 的表达。
Mol Ther. 2022 Apr 6;30(4):1597-1609. doi: 10.1016/j.ymthe.2022.01.038. Epub 2022 Feb 2.
6
New connections between ubiquitylation and methylation in the co-transcriptional histone modification network.泛素化和甲基化在转录组调控的组蛋白修饰网络中的新联系。
Curr Genet. 2021 Oct;67(5):695-705. doi: 10.1007/s00294-021-01196-x. Epub 2021 Jun 5.
7
The CTD Is Not Essential for the Post-Initiation Control of RNA Polymerase II Activity.CTD 对于 RNA 聚合酶 II 活性的起始后控制并非必需。
J Mol Biol. 2020 Sep 4;432(19):5489-5498. doi: 10.1016/j.jmb.2020.07.010. Epub 2020 Jul 21.
8
Epigenome-based splicing prediction using a recurrent neural network.基于表观基因组的剪接预测使用递归神经网络。
PLoS Comput Biol. 2020 Jun 25;16(6):e1008006. doi: 10.1371/journal.pcbi.1008006. eCollection 2020 Jun.
9
Spt5 Phosphorylation and the Rtf1 Plus3 Domain Promote Rtf1 Function through Distinct Mechanisms.Spt5 磷酸化和 Rtf1 Plus3 结构域通过不同的机制促进 Rtf1 的功能。
Mol Cell Biol. 2020 Jul 14;40(15). doi: 10.1128/MCB.00150-20.
10
SDG8 Potentiates the Sustainable Transcriptional Induction of the Genes and During Plant Defense Response.可持续发展目标8增强了植物防御反应过程中基因的可持续转录诱导。
Front Plant Sci. 2020 Mar 11;11:277. doi: 10.3389/fpls.2020.00277. eCollection 2020.

本文引用的文献

1
Role of somatic cancer mutations in human protein lysine methyltransferases.体细胞癌突变在人类蛋白质赖氨酸甲基转移酶中的作用。
Biochim Biophys Acta. 2014 Dec;1846(2):366-79. doi: 10.1016/j.bbcan.2014.08.002. Epub 2014 Aug 12.
2
How an mRNA capping enzyme reads distinct RNA polymerase II and Spt5 CTD phosphorylation codes.信使核糖核酸加帽酶如何识别不同的RNA聚合酶II和Spt5羧基末端结构域磷酸化编码。
Genes Dev. 2014 Jun 15;28(12):1323-36. doi: 10.1101/gad.242768.114.
3
H2B ubiquitylation promotes RNA Pol II processivity via PAF1 and pTEFb.H2B泛素化通过PAF1和pTEFb促进RNA聚合酶II的持续合成能力。
Mol Cell. 2014 Jun 19;54(6):920-931. doi: 10.1016/j.molcel.2014.04.013. Epub 2014 May 15.
4
The structure and substrate specificity of human Cdk12/Cyclin K.人类Cdk12/细胞周期蛋白K的结构与底物特异性。
Nat Commun. 2014 Mar 24;5:3505. doi: 10.1038/ncomms4505.
5
Writing and reading H2B monoubiquitylation.书写与阅读H2B单泛素化修饰
Biochim Biophys Acta. 2014 Aug;1839(8):694-701. doi: 10.1016/j.bbagrm.2014.01.002. Epub 2014 Jan 8.
6
The PAF complex and Prf1/Rtf1 delineate distinct Cdk9-dependent pathways regulating transcription elongation in fission yeast.PAF 复合物和 Prf1/Rtf1 划定了不同的 Cdk9 依赖性途径，调节裂殖酵母中转录延伸。
PLoS Genet. 2013;9(12):e1004029. doi: 10.1371/journal.pgen.1004029. Epub 2013 Dec 26.
7
A feed forward circuit comprising Spt6, Ctk1 and PAF regulates Pol II CTD phosphorylation and transcription elongation.一个前馈回路由 Spt6、Ctk1 和 PAF 组成，调节 Pol II CTD 磷酸化和转录延伸。
Nucleic Acids Res. 2014 Jan;42(2):870-81. doi: 10.1093/nar/gkt1003. Epub 2013 Oct 25.
8
Structural basis for Spt5-mediated recruitment of the Paf1 complex to chromatin.Spt5 介导 Paf1 复合物与染色质募集的结构基础。
Proc Natl Acad Sci U S A. 2013 Oct 22;110(43):17290-5. doi: 10.1073/pnas.1314754110. Epub 2013 Oct 7.
9
Spt6 regulates intragenic and antisense transcription, nucleosome positioning, and histone modifications genome-wide in fission yeast.Spt6 调节有义和反义转录、核小体定位和组蛋白修饰在裂殖酵母中的全基因组范围。
Mol Cell Biol. 2013 Dec;33(24):4779-92. doi: 10.1128/MCB.01068-13. Epub 2013 Oct 7.
10
Control of transcriptional elongation.转录延伸的控制。
Annu Rev Genet. 2013;47:483-508. doi: 10.1146/annurev-genet-110711-155440. Epub 2013 Sep 11.

RNA聚合酶II延伸复合物介导的染色质修饰。

Chromatin modification by the RNA Polymerase II elongation complex.

作者信息

Tanny Jason C

机构信息

a Department of Pharmacology and Therapeutics ; McGill University ; Montreal , Canada.

出版信息

Transcription. 2014;5(5):e988093. doi: 10.4161/21541264.2014.988093. Epub 2015 Jan 7.

DOI:10.4161/21541264.2014.988093
PMID:25494544
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4581355/
Abstract

Transcription elongation by RNA polymerase II (RNAP II) involves the coordinated action of numerous regulatory factors. Among these are chromatin-modifying enzymes, which generate a stereotypic and conserved pattern of histone modifications along transcribed genes. This pattern implies a precise coordination between regulators of histone modification and the RNAP II elongation complex. Here I review the pathways and molecular events that regulate co-transcriptional histone modifications. Insight into these events will illuminate the assembly of functional RNAP II elongation complexes and how the chromatin landscape influences their composition and function.

摘要

RNA聚合酶II（RNAP II）介导的转录延伸涉及众多调控因子的协同作用。其中包括染色质修饰酶，它们沿转录基因产生刻板且保守的组蛋白修饰模式。这种模式意味着组蛋白修饰调控因子与RNAP II延伸复合物之间存在精确的协调。在此，我综述了调控共转录组蛋白修饰的途径和分子事件。深入了解这些事件将阐明功能性RNAP II延伸复合物的组装，以及染色质景观如何影响其组成和功能。