Houle S, Yip T K, Shepherd F A, Rotstein L E, Sniderman K W, Theis E, Cawthorn R H, Richmond-Cox K
Department of Radiology, Toronto General Hospital, Ont, Canada.
Radiology. 1989 Sep;172(3):857-60. doi: 10.1148/radiology.172.3.2549567.
The potential use of yttrium-90 glass microspheres in the treatment of hepatocellular carcinoma was assessed in a pilot study of seven patients. The Y-90 microspheres were injected via a hepatic artery catheter. In this group of patients, no toxicity was observed for absorbed doses of between 5,000 and 10,000 cGy to the liver and up to 32,000 cGy to the tumor itself. Tumor response was seen only at the higher absorbed doses. The new Y-90 glass microspheres can safely deliver large doses of internal radiation to hepatic tumors as long as extrahepatic shunting can be excluded. Extrahepatic shunting will be the main limitation to this form of radiation therapy.
在一项针对7名患者的初步研究中，评估了钇-90玻璃微球在治疗肝细胞癌方面的潜在用途。钇-90微球通过肝动脉导管注入。在这组患者中，肝脏吸收剂量在5000至10000厘戈瑞之间，肿瘤本身吸收剂量高达32000厘戈瑞时，未观察到毒性反应。仅在较高吸收剂量时观察到肿瘤反应。只要能排除肝外分流，新型钇-90玻璃微球就能安全地向肝脏肿瘤输送大剂量内照射。肝外分流将是这种放射治疗形式的主要限制因素。
