Pearce Alison, Haas Marion, Viney Rosalie, Haywood Philip, Pearson Sallie-Anne, van Gool Kees, Srasuebkul Preeyaporn, Ward Robyn
University of Technology, Sydney, Centre for Health Economics Research and Evaluation, PO Box 123, Broadway, Australia.
Expert Rev Pharmacoecon Outcomes Res. 2015 Apr;15(2):215-22. doi: 10.1586/14737167.2015.990888. Epub 2014 Dec 11.
Many of the issues with using data from clinical trials and observational studies for economic evaluations are highlighted in the case of chemotherapy side effects. We present the results of an observational cohort study using linked administrative data. The chemotherapy side effects identified in the administrative data are compared with patient self-reports of such events. The results of these comparisons are then used to guide a discussion of the issues surrounding the use of administrative data to identify clinical events for the population of economic models. Although the advantages of easy access and generalizability of the results make administrative data an attractive option for populating economic models, this is not always possible because of the limitations of these data.
在化疗副作用的案例中，凸显了使用临床试验和观察性研究数据进行经济评估时存在的许多问题。我们展示了一项使用关联管理数据的观察性队列研究的结果。将管理数据中识别出的化疗副作用与患者对此类事件的自我报告进行比较。然后，这些比较结果被用于指导关于围绕使用管理数据来识别经济模型人群中的临床事件的相关问题的讨论。尽管易于获取和结果具有普遍性等优点使管理数据成为填充经济模型的一个有吸引力的选择，但由于这些数据的局限性，情况并非总是如此。
