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The potential of 12/15-lipoxygenase inhibitors in stroke therapy.

作者信息

van Leyen Klaus, Holman Theodore R, Maloney David J

机构信息

Neuroprotection Research Laboratory, Dept. of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA.

出版信息

Future Med Chem. 2014;6(17):1853-5. doi: 10.4155/fmc.14.129.

Abstract
摘要

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本文引用的文献

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Potent and selective inhibitors of human reticulocyte 12/15-lipoxygenase as anti-stroke therapies.
J Med Chem. 2014 May 22;57(10):4035-48. doi: 10.1021/jm401915r. Epub 2014 May 13.
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Heart disease and stroke statistics--2014 update: a report from the American Heart Association.
Circulation. 2014 Jan 21;129(3):e28-e292. doi: 10.1161/01.cir.0000441139.02102.80. Epub 2013 Dec 18.
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Inhibition of 12/15-lipoxygenase as therapeutic strategy to treat stroke.
Ann Neurol. 2013 Jan;73(1):129-35. doi: 10.1002/ana.23734. Epub 2012 Nov 28.
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Pyrazole-based sulfonamide and sulfamides as potent inhibitors of mammalian 15-lipoxygenase.
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