Zhang Yongfa, Lu Xiaoyang, Tai Bai, Li Weijia, Li Tao
Department of Neurosurgery, The First People's Hospital of Yunnan Province, Kunhua Hospital, The Affiliated Hospital of Kunming University of Science and Technology, Kunming, China.
Department of Neurosurgery, School of Medicine, The Second Affiliated Hospital, Zhejiang University, Hangzhou, China.
Front Cell Neurosci. 2021 Jun 3;15:615372. doi: 10.3389/fncel.2021.615372. eCollection 2021.
Ferroptosis is a unique regulated cell death defined by the intracellular iron overload and distinct biological features compared with other well-known programmed cell death. Ferroptosis can be triggered by many causes including decreased expression of glutathione (GSH), inhibition of the function of glutathione-dependent peroxidase 4 (GPX4), and system x , all of which finally lead to the over-accumulation of lipid peroxides in the cell. Ferroptosis has been reported to play an important role in the pathophysiological process of various cancers. In recent years, much evidence also proved that ferroptosis is involved in the progress of cerebral stroke. In this review, we summarized the characteristics of ferroptosis and the potential relationship between ferroptosis and ischemic and hemorrhagic stroke, to provide new targets and ideas for the therapy of stroke.
铁死亡是一种独特的程序性细胞死亡，其定义为细胞内铁过载以及与其他已知程序性细胞死亡相比具有独特的生物学特征。铁死亡可由多种原因触发，包括谷胱甘肽（GSH）表达降低、谷胱甘肽依赖性过氧化物酶4（GPX4）功能抑制以及系统x，所有这些最终都会导致细胞内脂质过氧化物的过度积累。据报道，铁死亡在各种癌症的病理生理过程中起重要作用。近年来，大量证据也证明铁死亡参与了脑卒中的进展。在这篇综述中，我们总结了铁死亡的特征以及铁死亡与缺血性和出血性脑卒中之间的潜在关系，为脑卒中治疗提供新的靶点和思路。
