Hamstra D A, de Kloet E R, van Hemert A M, de Rijk R H, Van der Does A J W
Institute of Psychology, Leiden University, The Netherlands; Leiden Institute of Brain and Cognition, Leiden University, The Netherlands.
Leiden Academic Centre of Drug Research, Leiden University, The Netherlands.
Neuroscience. 2015 Feb 12;286:412-22. doi: 10.1016/j.neuroscience.2014.12.004. Epub 2014 Dec 10.
Oral contraceptives (OCs) affect mood in some women and may have more subtle effects on emotional information processing in many more users. Female carriers of mineralocorticoid receptor (MR) haplotype 2 have been shown to be more optimistic and less vulnerable to depression.
To investigate the effects of oral contraceptives on emotional information processing and a possible moderating effect of MR haplotype.
Cross-sectional study in 85 healthy premenopausal women of West-European descent.
We found significant main effects of oral contraceptives on facial expression recognition, emotional memory and decision-making. Furthermore, carriers of MR haplotype 1 or 3 were sensitive to the impact of OCs on the recognition of sad and fearful faces and on emotional memory, whereas MR haplotype 2 carriers were not.
Different compounds of OCs were included. No hormonal measures were taken. Most naturally cycling participants were assessed in the luteal phase of their menstrual cycle.
Carriers of MR haplotype 2 may be less sensitive to depressogenic side-effects of OCs.
口服避孕药（OCs）会影响一些女性的情绪，并且可能对更多使用者的情绪信息处理产生更微妙的影响。已证明盐皮质激素受体（MR）单倍型2的女性携带者更乐观，且更不易患抑郁症。
研究口服避孕药对情绪信息处理的影响以及MR单倍型可能产生的调节作用。
对85名西欧血统的健康绝经前女性进行横断面研究。
我们发现口服避孕药对面部表情识别、情绪记忆和决策有显著的主要影响。此外，MR单倍型1或3的携带者对口服避孕药对悲伤和恐惧面孔识别以及情绪记忆的影响敏感，而MR单倍型2的携带者则不敏感。
纳入了不同成分的口服避孕药。未采取激素测量措施。大多数自然周期参与者是在月经周期的黄体期进行评估的。
MR单倍型2的携带者可能对口服避孕药的致抑郁副作用不太敏感。
