Jensen Marie Bjødstrup, Stawowy Marek, Christiansen Jens
Patologisk Institut, Regionshospitalet Randers, Skovlyvej 1, 8930 Randers NØ.
Ugeskr Laeger. 2014 Dec 15;176(25A).
Whipple's disease is a multisystemic infection with Tropheryma whipplei often characterised by its gastrointestinal involvement. However, due to the broad spectrum of unspecific symptoms, the diagnosis is often delayed. We report a case of a 70 year-old-man, who presented with extensive weight loss and lymphadenopathy. The diagnosis of Whipple's disease was made 18 months later on a duodenal biopsy. Retrospectively, it was discovered that a mesenterial biopsy taken earlier also revealed signs of Whipple's disease. Clinicians and pathologists need to be aware of this very rare and potentially fatal disease.
惠普尔病是一种由惠普尔嗜组织菌引起的多系统感染，常以胃肠道受累为特征。然而，由于症状缺乏特异性且范围广泛，诊断往往会延迟。我们报告一例70岁男性病例，该患者出现了体重大幅下降和淋巴结病。18个月后通过十二指肠活检确诊为惠普尔病。回顾发现，早期进行的肠系膜活检也显示出惠普尔病的迹象。临床医生和病理学家需要了解这种非常罕见且可能致命的疾病。
