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禽流感病毒 A(H7N9)的遗传修饰促进了不同物种内的病毒适应性。

Genetic tuning of avian influenza A (H7N9) virus promotes viral fitness within different species.

机构信息

Chinese National Influenza Center, National Institute for Viral Disease Control and Prevention, Key Laboratory of Surveillance and Early Warning on Infectious Disease, China CDC, Key Laboratory for Medical Virology, National Health and Family Planning Commission, 155 Changbai Road, Beijing 102206, PR China.

Chinese National Influenza Center, National Institute for Viral Disease Control and Prevention, Key Laboratory of Surveillance and Early Warning on Infectious Disease, China CDC, Key Laboratory for Medical Virology, National Health and Family Planning Commission, 155 Changbai Road, Beijing 102206, PR China.

出版信息

Microbes Infect. 2015 Feb;17(2):118-22. doi: 10.1016/j.micinf.2014.11.010. Epub 2014 Dec 11.

Abstract

Since their emergence in eastern China, novel influenza A (H7N9) viruses have been continuously circulating in poultry and causing human infections and death. We have proposed a "genetic tuning" mechanism for the genesis and evolution of the novel H7N9 virus during interspecies transmission.

摘要

自新型甲型流感病毒(H7N9)在中国东部出现以来,该病毒一直在禽类中持续传播,并导致人类感染和死亡。我们提出了一种“遗传调谐”机制,用于解释新型 H7N9 病毒在种间传播过程中的起源和进化。

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