子痫前期胎盘组织中胎盘miR-106a∼363簇表达失调。
Placental miR-106a∼363 cluster is dysregulated in preeclamptic placenta.
作者信息
Zhang C, Li Q, Ren N, Li C, Wang X, Xie M, Gao Z, Pan Z, Zhao C, Ren C, Yang W
机构信息
Department of Obstetrics, Affiliated Hospital of Weifang Medical University, Weifang, 261041, China.
Public Health College, Weifang Medical University, Weifang 261053, China.
出版信息
Placenta. 2015 Feb;36(2):250-2. doi: 10.1016/j.placenta.2014.11.020. Epub 2014 Dec 3.
Preeclampsia (PE) is the leading cause of maternal and perinatal mortality and morbidity. MicroRNAs are strongly implicated in the pathogenesis of this syndrome. In current study, we performed a microarray assay to explore miRNA expression profile in the placenta, and found 11 upregulated and 7 downregulated miRNAs in preeclampsia. miR-363, plus other 5 member of miR-106a∼363 cluster was further examined and validated. These findings would facilitate further investigation of aberrant expression of miRNAs in the pathology of preeclampsia.
子痫前期（PE）是孕产妇和围产儿发病和死亡的主要原因。微小RNA与该综合征的发病机制密切相关。在本研究中，我们进行了一项微阵列分析以探索胎盘组织中微小RNA的表达谱，发现子痫前期中有11种微小RNA上调，7种微小RNA下调。对miR-363以及miR-106a∼363簇的其他5个成员进行了进一步检测和验证。这些发现将有助于进一步研究微小RNA在子痫前期病理中的异常表达。
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