Menchetti L, Brecchia G, Canali C, Cardinali R, Polisca A, Zerani M, Boiti C
Dipartimento di Medicina Veterinaria, Università di Perugia, Via S. Costanzo 4, Perugia 06121, Italy.
Dipartimento di Medicina Veterinaria, Università di Perugia, Via S. Costanzo 4, Perugia 06121, Italy.
Res Vet Sci. 2015 Feb;98:7-12. doi: 10.1016/j.rvsc.2014.11.017. Epub 2014 Dec 2.
This study examined the effects of food restriction during rabbit pregnancy on hormones and metabolites involved in energy homeostasis and metabolic programming. Pregnant does were assigned to four groups: the control group was fed a standard ration while the others received a restricted amount of food (30% restriction) during early (0-9 days), mid (9-18 days), and late (19-28 days) pregnancy. The pregnancy induced a coordinated range of adaptations to fulfil energy requirements of both mother and foetus, such as hyperleptinaemia and hyperinsulinaemia, reduced insulin sensitivity, increased cortisol and non-esterified fatty acid. Food restriction altered leptin, insulin, T3, non-esterified fatty acids and glucose concentrations depending on the gestational phase in which it was applied. Collectively, present data confirm that the endocrinology of pregnancy and the adaptive responses to energy deficit make the rabbit an ideal model for studying nutritional-related disorders and foetal programming of metabolic disease.
本研究考察了家兔孕期食物限制对能量稳态及代谢编程中所涉及的激素和代谢物的影响。怀孕母兔被分为四组：对照组给予标准日粮，其他组在怀孕早期（0 - 9天）、中期（9 - 18天）和晚期（19 - 28天）接受限量食物（30%限制）。怀孕引发了一系列协调的适应性变化以满足母体和胎儿的能量需求，如高瘦素血症和高胰岛素血症、胰岛素敏感性降低、皮质醇和非酯化脂肪酸增加。食物限制会根据其实施的孕期阶段改变瘦素、胰岛素、T3、非酯化脂肪酸和葡萄糖浓度。总体而言，目前的数据证实，孕期内分泌学以及对能量缺乏的适应性反应使家兔成为研究营养相关疾病和胎儿代谢疾病编程的理想模型。
