Ortseifen Vera, Winkler Anika, Albersmeier Andreas, Wendler Sergej, Pühler Alfred, Kalinowski Jörn, Rückert Christian
Senior Research Group Genome Research of Industrial Microorganisms, Center for Biotechnology, Bielefeld University, Sequenz 1, 33615 Bielefeld, Germany; Microbial Genomics and Biotechnology, Center for Biotechnology, Bielefeld University, Sequenz 1, 33615 Bielefeld, Germany.
Technology Platform Genomics, Center for Biotechnology, Bielefeld University, Sequenz 1, 33615 Bielefeld, Germany.
J Biotechnol. 2015 Jan 20;194:81-3. doi: 10.1016/j.jbiotec.2014.11.036. Epub 2014 Dec 9.
Here we report the complete and finished genome sequence of Streptomyces glaucescens GLA.O (DSM 40922), a natural producer of the alpha-glucosidase inhibitor acarbose, which is used in the treatment of type-2 diabetes mellitus. The genome of S. glaucescens GLA.O consists of two replicons, the chromosome with a size of 7,453,200bp and a G+C content of 73.0% as well as a plasmid named pSglau1 with a size of 170,574bp and a G+C content of 69.06%.
在此，我们报告了灰色链霉菌GLA.O（DSM 40922）的完整基因组序列，它是α-葡萄糖苷酶抑制剂阿卡波糖的天然生产者，阿卡波糖用于治疗2型糖尿病。灰色链霉菌GLA.O的基因组由两个复制子组成，一个大小为7,453,200bp、G+C含量为73.0%的染色体，以及一个名为pSglau1的质粒，其大小为170,574bp、G+C含量为69.06%。
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