不同的GTP结合蛋白介导大鼠交感神经元中乙酰胆碱和去甲肾上腺素对钙通道的调节。
Different GTP-binding proteins mediate regulation of calcium channels by acetylcholine and noradrenaline in rat sympathetic neurons.
作者信息
Song S Y, Saito K, Noguchi K, Konishi S
机构信息
Laboratory of Cellular Physiology, Mitsubishi Kasei Institute of Life Sciences, Tokyo, Japan.
出版信息
Brain Res. 1989 Aug 14;494(2):383-6. doi: 10.1016/0006-8993(89)90609-4.
In dissociated neurons of rat superior cervical ganglion (SCG), noradrenaline (NA) and acetylcholine (ACh) suppressed Ca2+ currents elicited by depolarizations to 0 mV from -60 mV. With GTP-gamma-S in patch electrodes, ACh and NA caused persistent inhibition of Ca2+ currents. Pretreatment of SCG cells with pertussis toxin abolished the action of ACh but not of NA. The results suggest that ACh and NA reduce the Ca2+ currents in SCG cells through different G proteins.
在大鼠颈上神经节（SCG）的离体神经元中，去甲肾上腺素（NA）和乙酰胆碱（ACh）抑制了从-60 mV去极化至0 mV所引发的Ca2+电流。在膜片钳电极中加入GTP-γ-S后，ACh和NA对Ca2+电流产生持续性抑制。用百日咳毒素预处理SCG细胞可消除ACh的作用，但不影响NA的作用。结果表明，ACh和NA通过不同的G蛋白降低SCG细胞中的Ca2+电流。
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