Başak Kayhan, Kroğlu Kumru
From the Department of Pathology, Dr. Lütfi Kırdar Kartal Education and Research Hospital, Istanbul (KB); and Department of Pathology, Kırklareli State Hospital, Kırklareli, Turkey (KK).
Medicine (Baltimore). 2014 Dec;93(27):e246. doi: 10.1097/MD.0000000000000246.
Oncocytic cystadenoma is a benign tumor of salivary glands, histologically characterized by multicystic growth of the oncocytic epithelial lining. Crystals in different shapes and nature associate oncocytic type of salivary gland neoplasms. An 82 year-old woman with right parotideal mass had an operation of superficial parotidectomy. Histological examination revealed multiple unilocular or multilocular cystic lesions with incomplete fibrous capsule, papillary foldings, and 1 or 2 layers of oncocytic epithelium lines. The epithelium lining the cysts were positive for CK8, CK14, CK18, CK19, and negative for SMA, S-100, and p63 immunohistochemically. Cystadenomas were described as mostly multilocular and we presented a multifocal cystic neoplastic lesion lined by oncocytic type epithelial cells with intraluminal crystalloids. Multiple cysts forming morphology, incomplete fibrous capsule of most cysts and immunohistocemical findings were considered as multiple oncocytic cystadenoma with intraluminal crystalloids in the parotid gland.
嗜酸性细胞囊腺瘤是涎腺的一种良性肿瘤，组织学特征为嗜酸性上皮内衬呈多囊性生长。不同形状和性质的晶体与涎腺肿瘤的嗜酸性细胞类型相关。一名82岁右侧腮腺肿块的女性接受了腮腺浅叶切除术。组织学检查显示多个单房或多房囊性病变，有不完整的纤维包膜、乳头褶皱，以及1或2层嗜酸性上皮内衬。囊肿内衬上皮CK8、CK14、CK18、CK19免疫组化呈阳性，SMA、S-100和p63呈阴性。囊腺瘤大多被描述为多房性，我们展示了一个由嗜酸性细胞类型上皮细胞内衬并伴有管腔内晶体的多灶性囊性肿瘤性病变。多个囊肿形成的形态、大多数囊肿不完整的纤维包膜以及免疫组化结果被认为是腮腺内伴有管腔内晶体的多灶性嗜酸性细胞囊腺瘤。
