• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Enzymic synthesis of di- and tri-saccharide glycosides, using glycosidases and beta-D-galactoside 3-alpha-sialyl-transferase.

作者信息

Nilsson K G

机构信息

Carbohydrates International, Arlöv, Sweden.

出版信息

Carbohydr Res. 1989 Jun 1;188:9-17. doi: 10.1016/0008-6215(89)84053-4.

DOI:10.1016/0008-6215(89)84053-4
PMID:2550126
Abstract

The following disaccharide glycosides were obtained in yields of 10-35% from the appropriate donor and acceptor glycosides by employing glycosidases as catalysts: alpha-D-Galp-(1----3)-alpha-D-GalpNAc-OEt (alpha-D-galactosidase), beta-D-Galp-(1----3)-alpha-D-GalpNAc-OEt and beta-D-Galp-(1----3)-beta-D-GalpNAc-OEtBr (beta-D-galactosidase), beta-D-GlcpNAc-(1----6)-beta-D-Galp-OMe and beta-D-GlcpNAc-(1----6)-alpha-D-Manp-OMe (beta-N-acetylglucosaminidase). With beta-D-GlcpNAc-OEtSiMe3 as the acceptor, beta-D-galactosidase gave beta-D-Galp-(1----3)-beta-D-GlcpNAc-OEtSiMe3 almost exclusively, whereas, with beta-D-GlcpNAc-OMe as the acceptor, beta-D-Galp-(1----3)-beta-D-GlcpNAc-OMe was formed in only slightly excess over teh analogous beta-(1----4)-linked glycoside. The use of beta-D-galactosidase and beta-D-galactoside 3-alpha-sialyltransferase in sequence provided a convenient route to the trisaccharide glycosides alpha-D-Neup5Ac-(2----3)-beta-D-Galp-(1----3)-alpha-D-GalpNAc-OEt, alpha-D-Neup5Ac-(2----3)-beta-D-Galp-(1----3)-beta-D-GalpNAc-OE tBr, and alpha-D-Neup5Ac-(2----3)-beta-D-Galp-(1----3)-beta-D-GlcpNAc-OMe.

摘要

相似文献

1
Enzymic synthesis of di- and tri-saccharide glycosides, using glycosidases and beta-D-galactoside 3-alpha-sialyl-transferase.
Carbohydr Res. 1989 Jun 1;188:9-17. doi: 10.1016/0008-6215(89)84053-4.
2
Enzymic synthesis of HexNAc-containing disaccharide glycosides.
Carbohydr Res. 1990 Sep 5;204:79-83. doi: 10.1016/0008-6215(90)84022-m.
3
The use of porcine liver (2----3)-alpha-sialyltransferase in the large-scale synthesis of alpha-Neup5Ac-(2----3)-beta-D-Galp-(1----3)-D-GlcpNAc, the epitope of the tumor-associated carbohydrate antigen CA 50.
Carbohydr Res. 1992 Apr 10;228(1):137-44. doi: 10.1016/s0008-6215(00)90555-x.
4
A simple strategy for changing the regioselectivity of glycosidase-catalysed formation of disaccharides.一种改变糖苷酶催化形成二糖区域选择性的简单策略。
Carbohydr Res. 1987 Sep 15;167:95-103. doi: 10.1016/0008-6215(87)80271-9.
5
Enzymic synthesis of oligosaccharides terminating in the tumor-associated sialyl-Lewis-a determinant.
Carbohydr Res. 1989 Jul 1;190(1):1-11. doi: 10.1016/0008-6215(89)84141-2.
6
Synthesis of Hexp-(1-->4)-beta-D-GlcpNAc-(1-->2)-alpha-D-Manp-(1-->O) (CH2)7 CH3 probes for exploration of the substrate specificity of glycosyltransferases: Part II, Hex = 3-O-methyl-beta-D-Gal, 3-deoxy-beta-D-Gal, 3-deoxy-3-fluoro-beta-D-Gal, 3-amino-3-deoxy-beta-D-Gal, beta-D-Gul, alpha-L-Alt, or beta-L-Gal.用于探索糖基转移酶底物特异性的Hexp-(1→4)-β-D-GlcpNAc-(1→2)-α-D-Manp-(1→O)(CH₂)₇CH₃探针的合成：第二部分，Hex = 3-O-甲基-β-D-半乳糖、3-脱氧-β-D-半乳糖、3-脱氧-3-氟-β-D-半乳糖、3-氨基-3-脱氧-β-D-半乳糖、β-D-古洛糖、α-L-阿洛糖或β-L-半乳糖。
Carbohydr Res. 1997 Jan 17;297(3):209-27. doi: 10.1016/s0008-6215(96)00266-2.
7
Chemoenzymatic synthesis of 2-azidoethyl-ganglio-oligosaccharides GD3, GT3, GM2, GD2, GT2, GM1, and GD1a.2-叠氮乙基神经节寡糖GD3、GT3、GM2、GD2、GT2、GM1和GD1a的化学酶法合成。
Carbohydr Res. 2005 Sep 5;340(12):1963-72. doi: 10.1016/j.carres.2005.06.008.
8
The use of immobilised glycosyltransferases in the synthesis of sialyloligosaccharides.
Carbohydr Res. 1990 Apr 25;200:257-68. doi: 10.1016/0008-6215(90)84196-2.
9
Acceptor-substrate recognition by N-acetylglucosaminyltransferase-V: critical role of the 4"-hydroxyl group in beta-D-GlcpNAc-(1-->2)-alpha-D-Manp(1-->6)-beta-D-Glcp-OR.N-乙酰葡糖胺基转移酶-V对受体-底物的识别：β-D-葡萄糖胺-(1→2)-α-D-甘露糖(1→6)-β-D-葡萄糖-OR中4″-羟基的关键作用
Carbohydr Res. 1993 Apr 23;243(1):139-64. doi: 10.1016/0008-6215(93)84087-m.
10
Synthesis of the Sda determinant and two analogous tetrasaccharides.Sda决定簇及两种类似四糖的合成。
Carbohydr Res. 1997 Apr 21;299(3):181-95. doi: 10.1016/s0008-6215(97)00013-x.

引用本文的文献

1
Enzymic synthesis of lacto-N-triose II and its positional analogues.乳糖-N-三糖II及其位置类似物的酶促合成。
Glycoconj J. 1995 Oct;12(5):664-71. doi: 10.1007/BF00731263.