Department of Neurosurgery, Hospital Pablo Tobon Uribe, Clinica Medellin and Group of Genetics, Regeneration and Cancer, Universidad de Antioquia, Medellín, Colombia,
Pituitary. 2015 Apr;18(2):217-24. doi: 10.1007/s11102-014-0619-0.
Managing Cushing's disease remains a challenge. Surgery is the first option of treatment and it offers a high success rate. Even in cases where biochemical remission is not achieved, it is crucial to obtain surgical tissue for morphological diagnosis because the therapeutic approach can be modified according to the findings.
A literature search was performed using PubMed for information regarding pathology and Cushing's disease.
The histopathological features found in the pituitary gland of patients with Cushing's disease are presented.
Different subtypes of ACTH-producing pituitary tumors are recognized and characterized. The significance of finding a normal pituitary gland with or without Crooke's changes is also discussed.
库欣病的治疗仍然具有挑战性。手术是治疗的首选方法，其成功率较高。即使未能达到生化缓解，获得手术组织进行形态学诊断也至关重要，因为可以根据检查结果修改治疗方法。
使用 PubMed 进行文献检索，以获取有关病理学和库欣病的信息。
呈现了库欣病患者垂体中发现的组织病理学特征。
识别和描述了不同亚型的 ACTH 分泌性垂体肿瘤。还讨论了发现正常垂体伴有或不伴有 Crooke 样变的意义。
