速释型哌甲酯治疗儿童多动症的长期疗效
Long-Term Efficacy of Methylphenidate Immediate-Release for the Treatment of Childhood ADHD.
作者信息
Maia Carlos Renato Moreira, Cortese Samuele, Caye Arthur, Deakin Thomas Kuhn, Polanczyk Guilherme Vanoni, Polanczyk Carísi Anne, Rohde Luis Augusto Paim
机构信息
1 Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
2 Cambridge University Hospitals NHS Foundation Trust, Nottingham, UK.
出版信息
J Atten Disord. 2017 Jan;21(1):3-13. doi: 10.1177/1087054714559643. Epub 2016 Jul 28.
OBJECTIVE
To evaluate the long-term effects of methylphenidate imediate-release (MPH-IR), and to confirm the efficacy established in previous meta-analyses of short-term studies.
METHOD
Published and unpublished studies in which participants were treated with MPH-IR for 12 weeks or more were searched. Pooled effect sizes from these studies were computed with the DerSimonian and Laird random-effect model. Meta-regression analysis was conducted to estimate covariates associated with treatment effects.
RESULTS
Seven studies were included. Pooled parents ratings for inattention and hyperactivity/impulsivity resulted in standardized mean difference (SMD) = 0.96 (95% confidence interval [CI] = [0.60, 1.32]) and SMD = 1.12 (95% CI = [0.85, 1.39]), respectively; pooled teachers ratings showed SMD = 0.98 (95% CI = [0.09, 1.86]) for inattention and SMD = 1.25 (95% CI = [0.7, 1.81]) for hyperactivity/impulsivity. No evidence of association of any covariates with treatment effect was detected in the meta-regression.
CONCLUSION
MPH-IR is efficacious for childhood ADHD for periods longer than 12 weeks.
目的
评估速释哌甲酯（MPH-IR）的长期效果，并确认在先前短期研究的荟萃分析中所确立的疗效。
方法
检索已发表和未发表的研究，这些研究中参与者接受MPH-IR治疗12周或更长时间。使用DerSimonian和Laird随机效应模型计算这些研究的合并效应量。进行Meta回归分析以估计与治疗效果相关的协变量。
结果
纳入了七项研究。注意力不集中和多动/冲动的合并家长评分导致标准化均数差（SMD）分别为0.96（95%置信区间[CI]=[0.60,1.32]）和SMD=1.12（95%CI=[0.85,1.39]）；合并教师评分显示注意力不集中的SMD为0.98（95%CI=[0.09,1.86]），多动/冲动的SMD为1.25（95%CI=[0.7,1.81]）。在Meta回归中未检测到任何协变量与治疗效果相关的证据。
结论
MPH-IR对儿童多动症在超过12周的时间段内有效。
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