Stanley M W, Tani E M, Skoog L
Department of Pathology, Hennepin County Medical Center, Minneapolis, MN 55415.
Diagn Cytopathol. 1989;5(2):134-8. doi: 10.1002/dc.2840050205.
In its pure form, mucinous breast carcinoma (MC) has a much better prognosis than infiltrating ductal carcinoma (IDC). Mixed MC-IDC has the prognosis of IDC. We compared the fine-needle aspiration (FNA) cytology and histology of nine cases of pure MC with 13 cases of mixed MC-IDC. While typical of pure MC, abundant mucin (3+/3+) was noted in smears from three cases of mixed tumor and is thus necessary but not sufficient for a diagnosis of pure MC. Cellular pleomorphism has been said not to be a feature of MC; however, we found occasional large cells markedly different from the typical small uniform cells of MC in four pure and seven mixed tumors. Cytologic features indicative of a mixed tumor include one or more smears totally without mucin, scantly amounts of mucin, or necrosis. A combination of features indicative of pure mucinous carcinoma in FNA included abundant mucin on all smears, no pleomorphism, and no necrosis. Many cases will have smear patterns that are not typical of either profile and should probably be designated as carcinoma with a mucinous component.
纯黏液性乳腺癌（MC）的预后比浸润性导管癌（IDC）好得多。黏液性MC-IDC混合型的预后与IDC相同。我们比较了9例纯MC和13例黏液性MC-IDC混合型的细针穿刺（FNA）细胞学及组织学表现。虽然纯MC具有典型特征，但在3例混合型肿瘤的涂片中有丰富的黏液（3+/3+），因此黏液丰富是诊断纯MC的必要但不充分条件。细胞多形性一直被认为不是MC的特征；然而，我们在4例纯肿瘤和7例混合型肿瘤中发现了偶尔出现的大细胞，这些大细胞与典型的MC小而均匀的细胞明显不同。提示混合型肿瘤的细胞学特征包括一个或多个完全无黏液、黏液量少或有坏死的涂片。FNA中提示纯黏液性癌的特征组合包括所有涂片上黏液丰富、无多形性且无坏死。许多病例的涂片模式并非上述任何一种典型表现，可能应归类为伴有黏液成分的癌。
