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利用结构-功能联系数据库表征酶中的功能域。

Using the structure-function linkage database to characterize functional domains in enzymes.

作者信息

Brown Shoshana, Babbitt Patricia

机构信息

Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, California.

Department of Pharmaceutical Chemistry, School of Pharmacy, University of California, San Francisco, California.

出版信息

Curr Protoc Bioinformatics. 2014 Dec 12;48:2.10.1-2.10.16. doi: 10.1002/0471250953.bi0210s48.

DOI:10.1002/0471250953.bi0210s48
PMID:25501940
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4349220/
Abstract

The Structure-Function Linkage Database (SFLD; http://sfld.rbvi.ucsf.edu/) is a Web-accessible database designed to link enzyme sequence, structure, and functional information. This unit describes the protocols by which a user may query the database to predict the function of uncharacterized enzymes and to correct misannotated functional assignments. The information in this unit is especially useful in helping a user discriminate functional capabilities of a sequence that is only distantly related to characterized sequences in publicly available databases.

摘要

结构-功能联系数据库（SFLD；http://sfld.rbvi.ucsf.edu/）是一个可通过网络访问的数据库，旨在将酶的序列、结构和功能信息联系起来。本单元介绍了用户查询该数据库以预测未表征酶的功能并纠正错误注释的功能分配的协议。本单元中的信息对于帮助用户区分与公共可用数据库中已表征序列仅有远缘关系的序列的功能能力特别有用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd47/4349220/f3f881aab183/nihms-649995-f0001.jpg

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