Ulubaşoğlu Hasan, Özmen Bayar Ülkü, Kaya Cihan, Ungan Burcu
Dr Münif İslamǒglu State Hospital, Clinic of Obstetrics and Gynecology, Kastamonu, Turkey.
J Clin Ultrasound. 2015 Jun;43(5):322-6. doi: 10.1002/jcu.22252. Epub 2014 Dec 13.
The aim of this study was to evaluate the effect of oral nifedipine on Doppler indices of the uterine artery (UtA) and umbilical artery (UA) before and 24 hours, 48 hours, and 1 week after tocolytic treatment.
This was a prospective, self-controlled, cohort study of 65 pregnant women undergoing nifedipine tocolysis. Doppler assessment of the UtA and UA was performed before treatment and 24 hours, 48 hours, and 1 week after the initial 4 doses of 10 mg of oral nifedipine, administered at 20-minute intervals. The maintenance dosage was 20 mg of oral nifedipine administered every 6 hours for 48 hours, for a total dose of 80 mg/day.
There was a decrease in the 24-hour values of the UA pulsatility index, resistance index (RI), systolic-diastolic (S:D) ratio, right UtA pulsatility index, RI, S:D ratio, and left UtA RI and S:D ratio with nifedipine therapy in comparison with the values recorded prior to nifedipine therapy. However, these differences were not statistically significant. There were no statistically significant differences between the data recorded prior to nifedipine administration and those obtained at 48 hours and 1 week after treatment.
Oral nifedipine is a safe tocolytic agent with no long-term effect on fetomaternal circulation in pregnant women at risk of preterm delivery.
本研究旨在评估口服硝苯地平对宫缩抑制治疗前、治疗后24小时、48小时及1周时子宫动脉（UtA）和脐动脉（UA）多普勒指数的影响。
这是一项对65例接受硝苯地平宫缩抑制治疗的孕妇进行的前瞻性、自身对照队列研究。在治疗前以及初始4剂10 mg口服硝苯地平（每隔20分钟给药1次）后的24小时、48小时和1周时，对UtA和UA进行多普勒评估。维持剂量为每6小时口服20 mg硝苯地平，持续48小时，总剂量为80 mg/天。
与硝苯地平治疗前记录的值相比，硝苯地平治疗后UA搏动指数、阻力指数（RI）、收缩期与舒张期（S:D）比值、右侧UtA搏动指数、RI、S:D比值以及左侧UtA的RI和S:D比值在24小时时均有所下降。然而，这些差异无统计学意义。硝苯地平给药前记录的数据与治疗后48小时及1周时获得的数据之间无统计学显著差异。
口服硝苯地平是一种安全的宫缩抑制剂，对有早产风险的孕妇的母婴循环无长期影响。
