成功靶向卵巢癌肿瘤血管的新方法。
New ways to successfully target tumor vasculature in ovarian cancer.
作者信息
Yang Xiaoyun, Shen Fangrong, Hu Wei, Coleman Robert L, Sood Anil K
机构信息
aDepartment of Gynecologic Oncology and Reproductive Medicine bDepartment of Cancer Biology cCenter for RNA Interference and Non-Coding RNAs dDepartment of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA *Xiaoyun Yang and Fangrong Shen contributed equally to the writing of the article.
出版信息
Curr Opin Obstet Gynecol. 2015 Feb;27(1):58-65. doi: 10.1097/GCO.0000000000000136.
PURPOSE OF REVIEW
The aim of this article was to review the recent literature on potential therapeutic strategies for overcoming resistance to antivascular endothelial growth factor drugs in ovarian cancer.
RECENT FINDINGS
Although clinical benefits of antivascular endothelial growth factor therapy were observed in ovarian cancer treatment trials, this use yielded only modest improvement in progression-free survival and, with the exception of cediranib, no effect on overall survival. Adaptive resistance and escape from antiangiogenesis therapy is likely a multifactorial process, including induction of hypoxia, vascular modulators, and immune response. New drugs targeting the tumor vasculature or other components of the surrounding microenvironment have shown promising results.
SUMMARY
When to start and end antiangiogenesis therapy and the choice of optimal treatment combinations remain controversial. Further evaluation of personalized novel angiogenesis-based therapy is warranted. Defining the critical interaction of these agents and pathways and the appropriate predictive markers will become an increasingly important objective for effective treatment.
综述目的
本文旨在综述近期有关克服卵巢癌抗血管内皮生长因子药物耐药性的潜在治疗策略的文献。
最新发现
尽管在卵巢癌治疗试验中观察到抗血管内皮生长因子治疗具有临床益处，但这种治疗仅使无进展生存期有适度改善，且除西地尼布外，对总生存期无影响。适应性耐药和从抗血管生成治疗中逃逸可能是一个多因素过程，包括缺氧诱导、血管调节剂和免疫反应。靶向肿瘤血管或周围微环境其他成分的新药已显示出有前景的结果。
总结
抗血管生成治疗何时开始和结束以及最佳治疗组合的选择仍存在争议。有必要进一步评估基于个性化的新型血管生成治疗。确定这些药物和途径的关键相互作用以及合适的预测标志物将成为有效治疗日益重要的目标。
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