下丘泌素（食欲素）神经元及觉醒回路的光遗传学调控
Optogenetic control of hypocretin (orexin) neurons and arousal circuits.
作者信息
de Lecea Luis
机构信息
Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, 1201 Welch Rd, Stanford, CA, 94305, USA,
出版信息
Curr Top Behav Neurosci. 2015;25:367-78. doi: 10.1007/7854_2014_364.
Abstract
In 1998, our group discovered a cDNA that encoded the precursor of two putative neuropeptides that we called hypocretins for their hypothalamic expression and their similarity to the secretin family of neuropeptides. In the last 16 years, numerous studies have placed the hypocretin system as an integrator of homeostatic functions with a crucial, non-redundant function as arousal stabilizer. We recently applied optogenetic methods to interrogate the role of individual neuronal circuits in sleep-to-wake transitions. The neuronal connections between the hypocretin system and the locus coeruleus (LC) seem to be crucial in establishing the appropriate dynamic of spontaneous awakenings.
摘要
1998年，我们的研究小组发现了一种互补DNA（cDNA），它编码了两种假定神经肽的前体，由于它们在下丘脑的表达以及与神经肽促胰液素家族的相似性，我们将其称为下丘脑分泌素。在过去的16年里，大量研究表明下丘脑分泌素系统是稳态功能的整合者，作为唤醒稳定剂具有关键的、不可替代的作用。我们最近应用光遗传学方法来探究单个神经回路在睡眠到觉醒转换中的作用。下丘脑分泌素系统与蓝斑（LC）之间的神经连接似乎在建立适当的自发觉醒动态中起着关键作用。
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