下丘脑泌素作为代谢和觉醒的传感器。
The hypocretins as sensors for metabolism and arousal.
作者信息
Adamantidis Antoine, de Lecea Luis
机构信息
Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Palo Alto, CA 94304-5742, USA.
出版信息
J Physiol. 2009 Jan 15;587(1):33-40. doi: 10.1113/jphysiol.2008.164400. Epub 2008 Dec 1.
Abstract
Sleep disturbances are associated with hormonal imbalances and may result in metabolic disorders including obesity and diabetes. Therefore, circuits controlling both sleep and metabolism are likely to play a role in these physiopathological conditions. The hypocretin (Hcrt) system is a strong candidate for mediating both sleep and metabolic imbalances because Hcrt neurons are sensitive to metabolic hormones, including leptin and ghrelin, and modulate arousal and goal-orientated behaviours. This review discusses the role of Hcrt neurons as a sensors of energy balance and arousal and proposes new ways of probing local hypothalamic circuits regulating sleep and metabolism with unprecedented cellular specificity and temporal resolution.
摘要
睡眠障碍与激素失衡相关，可能导致包括肥胖和糖尿病在内的代谢紊乱。因此，控制睡眠和代谢的神经回路可能在这些病理生理状况中发挥作用。下丘脑泌素（Hcrt）系统很可能是介导睡眠和代谢失衡的关键因素，因为Hcrt神经元对包括瘦素和胃饥饿素在内的代谢激素敏感，并调节觉醒和目标导向行为。本文综述了Hcrt神经元作为能量平衡和觉醒传感器的作用，并提出了以前所未有的细胞特异性和时间分辨率探测调节睡眠和代谢的局部下丘脑神经回路的新方法。
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