Division of Hematology/Oncology, Department of Medicine, University of California, San Francisco, CA, U.S.A.
Department of Pathology, University of California, San Francisco, CA, U.S.A.
Anticancer Res. 2014 Dec;34(12):7357-60.
Overexpression of the human epidermal growth factor 2 (HER2) is associated with an aggressive metastatic phenotype in patients with breast cancer but its prognostic impact is not well-characterized in gastroesophageal adenocarcinoma.
This is a retrospective series of three cases of HER2-positive gastroesophageal cancer.
In this case series, we describe three patients presenting with widespread metastatic disease prior to development of symptoms from the primary tumor. Two patients presented with brain metastases, while one demonstrated lymphangitic spread to lungs.
Pooled analyses of outcomes among sub-populations of contemporary trials are needed to better understand the natural history and prognostic impact of HER2 over-expression in patients with gastroesophageal cancers.
人表皮生长因子 2（HER2）的过表达与乳腺癌患者侵袭性转移表型相关，但在胃食管腺癌中其预后影响尚未明确。
这是三例 HER2 阳性胃食管癌的回顾性系列研究。
在该病例系列中，我们描述了三例患者在出现原发性肿瘤症状之前就表现出广泛转移疾病。两名患者出现脑转移，而一名患者出现淋巴管扩散至肺部。
需要对当代试验的亚人群进行汇总分析，以更好地了解胃食管癌患者中 HER2 过表达的自然史和预后影响。
