Cádiz-Moretti Bernardita, Otero-García Marcos, Martínez-García Fernando, Lanuza Enrique
Laboratori de Neuroanatomia Funcional Comparada, Departaments de Biologia Cel·lular and Biologia Funcional, Facultat de Ciències Biològiques, Universitat de València, C/Dr. Moliner, 50, Burjassot, 46100, Valencia, Spain.
Unitat Predepartamental de Medicina, Fac. Ciències de la Salut, Universitat Jaume I, Av. Sos Baynat, s/n; Campus del Riu Sec, 12071, Castellón de la Plana, Spain.
Brain Struct Funct. 2016 Mar;221(2):1033-65. doi: 10.1007/s00429-014-0954-y. Epub 2014 Dec 11.
The medial amygdaloid nucleus (Me) is a key node in the socio-sexual brain, composed of anterior (MeA), posteroventral (MePV) and posterodorsal (MePD) subdivisions. These subdivisions have been suggested to play a different role in reproductive and defensive behaviours. In the present work we analyse the afferents of the three Me subdivisions using restricted injections of fluorogold in female outbred CD1 mice. The results reveal that the MeA, MePV and MePD share a common pattern of afferents, with some differences in the density of retrograde labelling in several nuclei. Common afferents to Me subdivisions include: the accessory olfactory bulbs, piriform cortex and endopiriform nucleus, chemosensory amygdala (receiving direct inputs from the olfactory bulbs), posterior part of the medial bed nucleus of the stria terminalis (BSTM), CA1 in the ventral hippocampus and posterior intralaminar thalamus. Minor projections originate from the basolateral amygdala and amygdalo-hippocampal area, septum, ventral striatum, several allocortical and periallocortical areas, claustrum, several hypothalamic structures, raphe and parabrachial complex. MeA and MePV share minor inputs from the frontal cortex (medial orbital, prelimbic, infralimbic and dorsal peduncular cortices), but differ in the lack of main olfactory projections to the MePV. By contrast, the MePD receives preferential projections from the rostral accessory olfactory bulb, the posteromedial BSTM and the ventral premammillary nucleus. In summary, the common pattern of afferents to the Me subdivisions and their interconnections suggest that they play cooperative instead of differential roles in the various behaviours (e.g., sociosexual, defensive) in which the Me has been shown to be involved.
内侧杏仁核（Me）是社会性行为大脑中的一个关键节点，由前部（MeA）、后腹侧（MePV）和后背侧（MePD）亚区组成。这些亚区在生殖和防御行为中被认为发挥着不同的作用。在本研究中，我们通过在雌性远交系CD1小鼠中限制性注射荧光金来分析Me三个亚区的传入神经。结果显示，MeA、MePV和MePD具有共同的传入神经模式，在几个核团中逆行标记的密度存在一些差异。Me亚区的共同传入神经包括：副嗅球、梨状皮质和内梨状核、化学感觉杏仁核（直接接收来自嗅球的输入）、终纹床核内侧部的后部（BSTM）、腹侧海马的CA1和丘脑后内侧核。少量投射起源于基底外侧杏仁核和杏仁核 - 海马区、隔区、腹侧纹状体、几个同型皮质和近同型皮质区域、屏状核、几个下丘脑结构、中缝和臂旁复合体。MeA和MePV从额叶皮质（内侧眶额、前边缘、边缘下和背侧脚状核皮质）接收少量输入，但不同之处在于MePV缺乏来自主嗅球的主要投射。相比之下，MePD优先接收来自吻侧副嗅球、BSTM后内侧部和腹侧乳头前核的投射。总之，Me亚区传入神经的共同模式及其相互连接表明，它们在Me已被证明参与的各种行为（如社会性行为、防御行为）中发挥协同而非不同的作用。
