在肺癌中经常缺失的多态性DNA探针的定位
Localization of polymorphic DNA probes frequently deleted in lung carcinoma.
作者信息
Albertson D G, Sherrington P D, Rabbitts P H
机构信息
MRC Molecular Genetics Unit, MRC Center, Cambridge, UK.
出版信息
Hum Genet. 1989 Sep;83(2):127-32. doi: 10.1007/BF00286704.
Five polymorphic DNA segments from human chromosome 3, that are frequently deleted in lung carcinoma were mapped by non-isotopic in situ hybridization to metaphase chromosomes. The DNA segment D3S3 mapped to 3p13-p14.2, D3S6 to 3p14.3-p14.5, D3S48 to distal 3p21-p22, ERBA beta to 3p24.3 and ERBA2 to 3p24.3. The map location of ERBA beta and ERBA2 was confirmed by re-mapping each probe in combination with D3S6 as a marker for 3p14.
来自人类3号染色体的五个多态性DNA片段，在肺癌中经常缺失，通过非同位素原位杂交定位到中期染色体上。DNA片段D3S3定位于3p13-p14.2，D3S6定位于3p14.3-p14.5，D3S48定位于3p21-p22远端，ERBAβ定位于3p24.3，ERBA2定位于3p24.3。通过将每个探针与作为3p14标记的D3S6联合重新定位，证实了ERBAβ和ERBA2的图谱位置。
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