Hadži-Lega Marija, Markova Ana Daneva, Stefanovic Milan, Tanturovski Mile
J Perinat Med. 2015 Sep;43(5):545-51. doi: 10.1515/jpm-2014-0275.
The aim of this study was to determine the relationship between sonographic cervical length, fetal fibronectin (fFN), phIGFBP-1 (actim partus test), cytokines (IL-6, IL-2R, and TNF-α), and spontaneous preterm birth (SPTB) up to 14 days from sampling.
Fifty-eight patients were recruited in a period of 6 months from September 2013 until March 2014 with symptoms or complaints suggestive of preterm labor. Consenting women were treated according to usual hospital protocol, with addition of vaginal swabs taken for fetal fibronectin, phIGFBP-1 (actim partus test) and cervical IL6, IL2R, and TNF-α. The outcome variable was occurrence of preterm delivery within 14 days from the day of hospital admission.
Thirty-six patients (62.07%) were delivered within 14 days from admission. Our results indicated that the cervical length significantly inversely correlates with the concentration of IL-6 in the CVF (Spearman's coefficient R=-0.382, P<0.05). Cervical length also correlated with a positive phIGFBP-1 test, i.e., patients with a positive test had an average cervical length of 18.5±4.63 mm, which is significantly lower than patients with a negative test -23.43±7.39 mm (P=0.003).
The studied biochemical markers were only moderately successful in the prediction of preterm delivery.
本研究旨在确定超声测量的宫颈长度、胎儿纤连蛋白（fFN）、妊娠相关胰岛素样生长因子结合蛋白-1（phIGFBP-1，即活化分娩试验）、细胞因子（白细胞介素-6、白细胞介素-2受体和肿瘤坏死因子-α）与采样后14天内自发性早产（SPTB）之间的关系。
2013年9月至2014年3月的6个月期间，招募了58例有早产迹象或症状的患者。同意参与的女性按照医院常规方案进行治疗，并额外采集阴道拭子检测胎儿纤连蛋白、phIGFBP-1（活化分娩试验）以及宫颈白细胞介素-6、白细胞介素-2受体和肿瘤坏死因子-α。观察的变量为入院后14天内早产的发生情况。
36例患者（62.07%）在入院后14天内分娩。我们的结果表明，宫颈长度与宫颈阴道液中白细胞介素-6的浓度显著负相关（斯皮尔曼系数R = -0.382，P < 0.05）。宫颈长度也与phIGFBP-1试验阳性相关，即试验阳性的患者宫颈平均长度为18.5±4.63毫米，显著低于试验阴性患者的23.43±7.39毫米（P = 0.003）。
所研究的生化标志物在预测早产方面仅取得了一定程度的成功。
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