Danti Luana, Prefumo Federico, Lojacono Andrea, Corini Silvia, Testori Alberto, Frusca Tiziana
Maternal-Fetal Medicine Unit, Department of Obstetrics and Gynaecology, University of Brescia, Italy.
J Matern Fetal Neonatal Med. 2011 Oct;24(10):1262-6. doi: 10.3109/14767058.2010.547962. Epub 2011 Jan 19.
To assess the combined use of cervical length and cervical phosphorylated insulin-like growth factor binding protein-1 (phIGFBP-1) in the prediction of preterm delivery in symptomatic women.
Cervical length was prospectively measured in 102 consecutive singleton pregnancies with intact membranes and regular contractions at 24-32 weeks, and phIGFBP-1 was assessed in those with a cervix ≤30 mm.
Among women with a cervix >30 mm (n = 42), none delivered <34 weeks or within 7 days. Among women with a cervical length ≤30 mm (n = 60), eight delivered <34 weeks, four of which within 7 days. A positive phIGFBP-1 conferred a significantly increased risk of delivery before 34 weeks in women with a cervix ≤30 mm (likelihood ratio 2.32, 95% confidence interval 1.15-4.67), and a significantly increased risk of delivering within 7 days in the subgroup of women with a cervical length of 20-30 mm (likelihood ratio 3.64, 95% confidence interval 2.20-6.01).
In symptomatic women with a cervical length >30 mm the risk of preterm delivery is very low. In women with a cervix ≤30 mm, adding phIGFBP-1 assessment may improve the risk assessment for preterm delivery, and help to plan subsequent pregnancy management.
评估宫颈长度和宫颈磷酸化胰岛素样生长因子结合蛋白-1（phIGFBP-1）联合使用对有症状孕妇早产的预测价值。
对102例孕24 - 32周、胎膜完整且有规律宫缩的单胎妊娠孕妇前瞻性测量宫颈长度，对宫颈长度≤30 mm的孕妇评估phIGFBP-1。
宫颈长度>30 mm的孕妇（n = 42）中，无一人在34周前或7天内分娩。宫颈长度≤30 mm的孕妇（n = 60）中，8人在34周前分娩，其中4人在7天内分娩。phIGFBP-1阳性使宫颈长度≤30 mm的孕妇在34周前分娩的风险显著增加（似然比2.32，95%置信区间1.15 - 4.67），使宫颈长度为20 - 30 mm的孕妇亚组在7天内分娩的风险显著增加（似然比3.
