Goral Simin, Brukamp Kirsten, Ticehurst Erin H, Abt Peter L, Bloom Roy D, Kearns Jane, Constantinescu Serban, Kamoun Malek, Tomaszewski John
Hospital of the University of Pennsylvania, Department of Medicine, Renal, Electrolyte, and Hypertension Division, Philadelphia, Pa., USA.
Am J Nephrol. 2014;40(5):491-8. doi: 10.1159/000369865. Epub 2014 Dec 9.
To identify the histopathological features of transplant nephrectomy (TN) specimens.
We performed retrospective analysis of 73 nephrectomies to review the histopathology in detail and correlate the Banff grading characteristics of TN specimens with time post engraftment and clinical features. Retrospective data on donor-specific antibodies (DSA) were also collected.
The majority of patients who had TN in less than 3 months posttransplant (n = 20; median time to TN: 4 days) had hemorrhagic infarction; 7 patients (35%) had grade 3 acute rejection (AR). Patients who had TN later than 3 months posttransplant (n = 53; median time to TN: 67 months) had AR, grade 2B (21%) and 3 (43%), coexisting with advanced vascular injury in the form of interstitial hemorrhage, extensive interstitial fibrosis and tubular atrophy (IF/TA) as well as the presence of DSAs. Overall, the majority of patients without DSA pre-TN developed DSA post-TN.
Our data revealed extensive inflammation and ongoing immunologic activity in a subset of patients with a failed graft. Careful and individualized approach based on clinical and laboratory data should guide the decision for transplant nephrectomy.
