Osorio Natalia, López Yúrika, Jaramillo Juan Camilo
Servicio de Pediatría, Hospital General de Medellín, Medellín, Colombia.
Facultad de Medicina, Universidad CES, Medellín, Colombia.
Biomedica. 2014 Oct-Dec;34(4):506-13. doi: 10.1590/S0120-41572014000400002.
Histoplasmosis is a multifaceted condition caused by the dimorphic fungi Histoplasma capsulatum whose infective spores are inhaled and reach the lungs, the primary organ of infection. The meningeal form, considered one of the most serious manifestations of this mycosis, is usually seen in individuals with impaired cellular immunity such as patients with acquired immunodeficiency syndrome, systemic lupus erythematous or solid organ transplantation, and infants given their immunological immaturity. The most common presentation is self-limited and occurs in immunocompetent individuals who have been exposed to high concentrations of conidia and mycelia fragments of the fungi. In those people, the condition is manifested by pulmonary disorders and late dissemination to other organs and systems. We report a case of central nervous system histoplasmosis in an immunocompetent child.
组织胞浆菌病是一种由双相真菌荚膜组织胞浆菌引起的多方面病症，其感染性孢子被吸入并到达肺部，肺部是主要的感染器官。脑膜型组织胞浆菌病被认为是这种真菌病最严重的表现之一，通常见于细胞免疫受损的个体，如获得性免疫缺陷综合征患者、系统性红斑狼疮患者或实体器官移植患者，以及因免疫不成熟的婴儿。最常见的表现是自限性的，发生在接触过高浓度真菌分生孢子和菌丝体片段的免疫功能正常的个体中。在这些人身上，病情表现为肺部疾病，并晚期扩散到其他器官和系统。我们报告一例免疫功能正常儿童的中枢神经系统组织胞浆菌病病例。
