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1
Click chemistry for drug development and diverse chemical-biology applications.
Chem Rev. 2013 Jul 10;113(7):4905-79. doi: 10.1021/cr200409f. Epub 2013 Mar 27.
2
The impact of click chemistry in medicinal chemistry.
Expert Opin Drug Discov. 2012 Jun;7(6):489-501. doi: 10.1517/17460441.2012.682725. Epub 2012 May 19.
3
Inhibition of cell migration by PITENINs: the role of ARF6.
Oncogene. 2012 Sep 27;31(39):4317-32. doi: 10.1038/onc.2011.593. Epub 2011 Dec 19.
4
Click chemistry: 1,2,3-triazoles as pharmacophores.
Chem Asian J. 2011 Oct 4;6(10):2696-718. doi: 10.1002/asia.201100432. Epub 2011 Aug 29.
5
Small-molecule inhibitors of the PI3K signaling network.
Future Med Chem. 2011 Apr;3(5):549-65. doi: 10.4155/fmc.11.12.
6
Non-nucleoside building blocks for copper-assisted and copper-free click chemistry for the efficient synthesis of RNA conjugates.
Org Lett. 2010 Dec 3;12(23):5410-3. doi: 10.1021/ol102205j. Epub 2010 Nov 4.
7
Small molecule inhibition of phosphatidylinositol-3,4,5-triphosphate (PIP3) binding to pleckstrin homology domains.
Proc Natl Acad Sci U S A. 2010 Nov 16;107(46):20126-31. doi: 10.1073/pnas.1004522107. Epub 2010 Nov 1.
8
Targeting the PI3K signaling pathway in cancer.
Curr Opin Genet Dev. 2010 Feb;20(1):87-90. doi: 10.1016/j.gde.2009.11.002. Epub 2009 Dec 16.
9
Evaluation of triazolamers as active site inhibitors of HIV-1 protease.
Bioorg Med Chem Lett. 2009 Nov 1;19(21):6023-6. doi: 10.1016/j.bmcl.2009.09.049. Epub 2009 Sep 17.
10
In vitro cytotoxicity of novel pro-apoptotic agent DM-PIT-1 in PEG-PE-based micelles alone and in combination with TRAIL.
Drug Deliv. 2009 Jan;16(1):45-51. doi: 10.1080/10717540802517951.
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