Synthesis and Biological Activities of Ethyl 2-(2-pyridylacetate) Derivatives Containing Thiourea, 1,2,4-triazole, Thiadiazole and Oxadiazole Moieties.

Thirty six novel heterocyclic derivatives of ethyl 2-(2-pyridylacetate) were efficiently synthesized. The new compounds involve the linkage of a 2-pyridyl ring with thiosemicarbazide (compounds -), 1,2,4-triazole (compounds -), 1,3,4-thiadiazole (compounds -), and 1,3,4-oxadiazole (compounds -) moieties. The last group of compounds - involves the connection of a 2-pyridyl ring with 1,2,4-triazole and thiourea. ¹H-NMR, C-NMR and MS methods were used to confirm the structures of the obtained derivatives. The molecular structures of , , and were further confirmed by X-ray crystallography. All obtained compounds were tested in vitro against a number of microorganisms, including Gram-positive cocci, Gram-negative rods and . In addition, the obtained compounds were tested for cytotoxicity and antiviral activity against HIV-1.