L-麻黄碱对离体豚鼠回肠胆碱能神经传递的影响。
Effect of l-ephedrine on cholinergic neurotransmission in the isolated guinea pig ileum.
作者信息
Yamamoto R, Nuki C, Komidori H, Takasaki K
机构信息
Department of Pharmacology, Miyazaki Medical College, Japan.
出版信息
Jpn J Pharmacol. 1989 Aug;50(4):511-4. doi: 10.1254/jjp.50.511.
In the isolated guinea pig ileum, the effects of I-ephedrine on the twitch response to field stimulation were investigated in the presence of propranolol. Ephedrine and clonidine inhibited the twitch response but not the contraction to exogenous acetylcholine. The inhibitory effect of clonidine was significantly diminished by yohimbine pretreatment. However, the inhibitory effect of ephedrine was not influenced by yohimbine, sulpiride or 6-hydroxydopamine (6-OHDA) pretreatment. Most of this action of ephedrine appeared to be cholinergic prejunctional in nature, but unrelated to activation of prejunctional alpha 2-adrenoceptors and dopamine sensitive receptors on the cholinergic nerves in this preparation.
在离体豚鼠回肠中，在普萘洛尔存在的情况下研究了L-麻黄碱对场刺激引起的抽搐反应的影响。麻黄碱和可乐定抑制抽搐反应，但不抑制对外源性乙酰胆碱的收缩反应。育亨宾预处理可显著减弱可乐定的抑制作用。然而，麻黄碱的抑制作用不受育亨宾、舒必利或6-羟基多巴胺（6-OHDA）预处理的影响。麻黄碱的这种作用大部分似乎本质上是胆碱能节前性的，但与该制剂中胆碱能神经上的节前α2-肾上腺素能受体和多巴胺敏感受体的激活无关。
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