肾母细胞瘤的细胞遗传学分析：多步骤过程的证据

Cytogenetic analysis of Wilms' tumor: evidence of a multistep process.

作者信息

Vekemans M, De Braekeleer M, de Chadarevian J P

机构信息

Department of Pediatric Pathology, McGill University, Montreal, Chicoutimi, Canada.

出版信息

Oncology. 1989;46(5):306-9. doi: 10.1159/000226738.

DOI:10.1159/000226738

PMID:2550862

Abstract

We report the cytogenetic findings observed in the cancer cells of a Wilms' tumor in a 11-month-old girl without the phenotype of the WAGR. Two populations were identified: one had a 46,XX,del(11)(p11p13) karyotype and the other had a translocation involving the deleted chromosome 11 and chromosome 12, t(11;12)(p11;q13). This result strongly suggests that the deletion of 11p was the initiating event to the tumor and that the translocation has been instrumental in promoting its development.

摘要

我们报告了一名11个月大、无WAGR综合征表型的女孩肾母细胞瘤癌细胞中的细胞遗传学发现。鉴定出两个细胞群：一个具有46,XX,del(11)(p11p13)核型，另一个具有涉及缺失的11号染色体和12号染色体的易位，即t(11;12)(p11;q13)。这一结果强烈表明，11p的缺失是肿瘤发生的起始事件，而该易位在促进肿瘤发展中起到了作用。