长期溃疡性结肠炎合并套细胞淋巴瘤转化为弥漫性大B细胞淋巴瘤。

Long-standing ulcerative colitis complicated with mantle-cell lymphoma transformed in diffuse large B cell lymphoma.

作者信息

Popp Cristiana, Stăniceanu Florica, Micu Gianina, Nichita Luciana, Mateescu R M, Dimitriui Liliana, Sticlaru Liana

出版信息

Rom J Intern Med. 2014;52(3):176-82.

Abstract

Ulcerative colitis (UC) is a chronic, relapsing inflammatory disease of the colon and rectum. Its etiology and pathogenesis are incompletely elucidated, although there are many studies concerning these problems. Chronic inflammation and immunosuppressive treatment are risk factors for epithelial and lymphoid malignancies. We present a case of a 39-year-old man who died after a long-standing untreated UC complicated with mantle cell colonic lymphoma and then with transformation towards a high grade diffuse large B cell lymphoma. Multiple colonic biopsies were collected in various moments of the disease. Microscopic and immunohistochemical features are comparatively presented. This case emphasizes the importance of constant surveillance for UC patients and reaffirms the role of multidisciplinary approach in UC management.

摘要

溃疡性结肠炎（UC）是一种结肠和直肠的慢性复发性炎症性疾病。尽管有许多关于这些问题的研究，但其病因和发病机制尚未完全阐明。慢性炎症和免疫抑制治疗是上皮性和淋巴样恶性肿瘤的危险因素。我们报告一例39岁男性病例，该患者长期未经治疗的UC并发套细胞结肠淋巴瘤，随后转变为高级别弥漫性大B细胞淋巴瘤后死亡。在疾病的不同阶段采集了多次结肠活检样本。对微观和免疫组化特征进行了比较呈现。该病例强调了对UC患者持续监测的重要性，并再次肯定了多学科方法在UC管理中的作用。